Whole Body Hyperthermia:German View

Summary

Whole Body Hyperthermia

During the last decades basic research has produced substantial evidence that the antitumor cytotoxicity of selected drugs and radiotherapy can be enhanced by heat exposure.

Randomized phase 3 trials have shown a benefit for radiotherapy plus locoregional hyperthermia. Whole body hyperthermia is not yet standard in the treatment of systemic malignancies, and the final proof of its effectiveness by phase 3 studies is still missing.

For years the method was hampered by insufficient heating techniques. Only recently, through the development of a radiant heat device, gentle heating of patients was made possible, thus allowing for the initiation of urgently needed multicentre trials.

Common criteria regarding inclusion and the treatment technique of whole body hyperthermia in combination with chemotherapy have to be implemented to guarantee that the results of these trials are meaningful.

Per our German contact: "What I found odd is that I found it as a link on the Oncotherm site( St. Georg WBH), though the three manufacturers mentioned in the article are Enthermics(not found on G web), Aquatherm(mattress), and Iratherm(Ardenne). http://www.oncotherm.de/german/studien_publikationen.htm"

Dt Ärztebl 2000; 97: A 2941-2946 [Heft 44]

Ganzkörper-Hyperthermie in Kombination mit Chemotherapie

Susanna Hegewisch-Becker1 Elke Jäger2 Alexander Knuth2 Hanno Riess3 Günter Josef Wiedemann4 Dieter Kurt Hossfeld1

Anschrift für die Verfasser: Prof. Dr. med. Susanna Hegewisch-Becker Abteilung für Onkologie und Hämatologie Universitätsklinikum Eppendorf Martinistraße 52 20246 Hamburg E-Mail: hegewisc@uke.uni-hamburg.de

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