Whey, Glutamine & Transforming Growth Factor-β w/Mucositis

Ann's NOTE: This study was done on rats. What it shows is that the combination of these nutritional supplements are able to reduce the amount of intestinal mucositis (chemotherapy kills fast-growing cells whether healthy or cancerous). The lining of the intestines and throat are such cells. So if this combination acts to protect the cells from damage, that is terrific. The Annie Appleseed Project would like to see these kinds of studies in human beings but the issue is COST. It is very expensive to set up human trials and right now only the wealthy pharmaceutical industry can afford to do it (for the most part).

So we have to take our ideas from animal studies. Also we strongly favor the combinations of healthy behaviors so adding fish oil - Omega-3 to this mix might be a good idea. Taking exercise daily while receiving cancer treatment has been shown to be helpful to the body (we have these studies in our section on Studies).

Nutrition and Disease

A Diet Containing Whey Protein, Free Glutamine, and Transforming Growth Factor-β Ameliorates Nutritional Outcome and Intestinal Mucositis during Repeated Chemotherapeutic Challenges in Rats1–3,

Nabile Boukhettala4, Ayman Ibrahim4, Moutaz Aziz5, Jacques Vuichoud6, Kim-Yen Saudan6, Stéphanie Blum6, Pierre Déchelotte4,*, Denis Breuillé6 and Moïse Coëffier4

4 Nutrition Unit, Rouen University Hospital, Rouen, France and ADEN–EA4311, Institute for Biomedical Research and European Institute for Peptide Research, Rouen University, Rouen F-76183, France; 5 Laboratory of Anatomo-Pathology, Rouen University Hospital, Rouen, France; 6 Nestlé Research Center, Nutrition and Health Department, Lausanne CH-1000, Switzerland

Anticancer chemotherapy often induces side effects such as mucositis. Recent data suggest that a diet, Clinutren Protect (CP), containing whey proteins, glutamine, and transforming growth factor-β (TGFβ)-rich casein limits intestinal mucositis and improves recovery after a single methotrexate (MTX) challenge in rats.

Chemotherapy consists of alternating periods of treatment and rest. Thus, our study evaluated the effects of CP on nutritional outcome and intestinal mucositis in rats receiving repeated chemotherapeutic challenges.

Thirty-six Sprague-Dawley rats received 3 cycles of MTX at 8-d intervals. Rats had free access to CP or control diet (Co) from 7 d before the first MTX injection until the end of the experiment at d 27. In Co, whey proteins and TGFβ-rich casein were replaced by TGFβ-free casein.

L-Glutamine was replaced by L-alanine. Body composition was assessed by dual energy X-ray absorptiometry. Before MTX challenges, food intake and body weight were similar in both groups but became higher during MTX challenges in CP (P < 0.05).

Fat mass decreased similarly in both groups. In contrast, the decrease of fat free mass between d –1 and d 27 was less pronounced in the CP group (–9.5 g) than in the Co group (–57.2 g) (P < 0.05). The intestinal damage score was lower in the CP group (0.6 ± 0.3 vs. 2.1 ± 0.6; P < 0.05). Fecal IgA increased over time in the CP group (P < 0.05) but not in the Co group.

A diet containing whey proteins, glutamine, and TGFβ improves nutritional outcome by limiting the reduction of fat free mass and reduces intestinal mucositis during repeated chemotherapeutic challenges in rats.

J. Nutr. First published February 24, 2010; doi:10.3945/jn.109.119222 Journal of Nutrition, doi:10.3945/jn.109.119222 Vol. 140, No. 4, 799-805, April 2010

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