ABSTRACT: Association of vitamin D receptor gene polymorphism
with sporadic breast cancer in Taiwanese patients
Purpose: Previous reports have suggested that polymorphism in
the vitamin D receptor (VDR) gene is associated with sporadic
breast cancer, but there is controversy among different authors
and ethnic groups.
The purpose of this study was to determine
whether polymorphism in the VDR gene might also influence breast
cancer risk in Taiwan, a country with a low incidence of breast cancer.
Conclusion: These results suggest that polymorphic variation in
or near the 3 cent end of the VDR gene may influence breast cancer
risk in Taiwanese women and justifies further investigation of the
role of VDR for sporadic breast cancer in low-incidence areas.
These findings also should help when designing targeted therapy.
[06/27/2002; Breast Cancer Research and Treatment]
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