ABSTRACT: Tumour markers in breast carcinoma correlate with grade
rather than with invasiveness
[09/14/2001; British Journal of Cancer]
Ductal breast carcinoma in situ (DCIS) is regarded as a precursor
to invasive breast cancer. The progression from in situ to invasive
cancer is however little understood. We compared some tumour
markers in invasive and in situ breast carcinomas trying to find
steps in this progression.
We designed a semi-experimental setting
and compared histopathological grading and tumour marker expression
in pure DCIS (n = 194), small invasive lesions (n = 127) and
lesions with both an invasive and in situ component (n = 305).
Grading was done according to the Elston-Ellis and EORTC classification
systems, respectively. Immunohistochemical staining was conducted
for p53, c-erbB-2, Ki-67, ER, PR, bcl-2 and angiogenesis. All
markers correlated with grade rather than with invasiveness.
No marker was clearly associated with the progression from in
situ to invasiveness.
The expression of tumour markers was almost
identical in the 2 components of mixed lesions. DCIS as a group
showed a more 'malignant picture' than invasive cancer according
to the markers, probably, due to a higher proportion of poorly
The step between in situ and invasive
cancer seems to occur independently of tumour grade. The results
suggest that well-differentiated DCIS progress to well-differentiated
invasive cancer and poorly differentiated DCIS progress to poorly
differentiated invasive cancer.
J Japanese Breast Cancer Soc, 3/02
Cancer Online, 4/02
Arch Surg, 5/03
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