The daily oscillations of biological processes, known as circadian
rhythms, are regulated by genetically controlled endogenous clocks.
Disruptions in circadian rhythms have been associated with cancer -
people and animals with irregular sleep-wake cycles are more susceptible
to certain cancers, and the efficacy and toxicity of some chemotherapy
agents correlate with the timing of drug delivery.
A recent study by Fu
et al. reported that mice with targeted disruption in a circadian
control gene develop tumours, providing the opportunity to study the
molecular basis of this relationship.
So far, eight core circadian genes have been identified. Among these are
the Per1, 2 and 3 genes, which encode non-DNA-binding nuclear factors.
The expression of these genes oscillates over the 24-hour circadian
period. Mice with a homozygous mutation in Per2 (mPer2m/m) have been
previously reported to be deficient in circadian clock function.
4 October issue of Cell, Fu et al. report that these mice have
neoplastic phenotypes, such as salivary-gland hyperplasia and teratoma
formation, reduced levels of thymic apoptosis .
Nature Reviews Cancer (2002)
Thanks to Healthday.com, 11/03
Proceeding of the National Acadmeny of Sciences,
|Remember we are NOT Doctors and have NO medical training.|
This site is like an Encyclopedia - there are many pages, many links on many topics.
Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.