Triphala (Ayurvedic Drug) Protects Mice from RTX Troubles

Triphala, an Ayurvedic Rasayana Drug, Protects Mice Against Radiation-Induced Lethality by Free-Radical Scavenging

Ganesh Chandra Jagetia, Ph.D. Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka India. Krishna J. Malagi, M.D. (Ayu) Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka India. Manjeshwar Shrinath Baliga, Ph.D. Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka India. Ponemone Venkatesh, M.Sc. (Medical) Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka India. Rosi Reddy Veruva, M.Pharm. Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka India.

The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality in mice exposed to 712 Gray (Gy) of -irradiation.

Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW).

Triphala provided protection against both gastrointestinal and hemopoetic death. However, animals of both the TE + irradiation and DDW + irradiation groups did not survive up to 30 days post-irradiation beyond 11 Gy irradiation.

The LD50/30 was found to be 8.6 Gy for the DDW + irradiation group and 9.9 Gy for TE + irradiation group. The administration of triphala resulted in an increase in the radiation tolerance by 1.4 Gy, and the dose reduction factor was found to be 1.15. To understand the mechanism of action of triphala, the free radical scavenging activity of the drug was evaluated.

Triphala was found to scavenge OH, O2 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonate) diammonium salt (ABTS)+ and NO radicals in a dose dependent manner.

Journal of Alternative and Complementary Medicine, Dec 2004, Vol. 10, No. 6: 971-978

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