In vitro and in vivo antimetastatic effects of Terminalia catappa L. leaves on lung cancer cells
Shu-Chen Chua, Shun-Fa Yangb, 1, Shang-Jung Liuc, Wu-Hsien Kuod, e, Yan-Zin Changf and Yih-Shou Hsiehc,
aDepartment of Food Science, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
bInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
cInstitute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan
dDivision of Gastroenterology, Department of Internal Medicine, Armed-Forces Taichung General Hospital, Taichung, Taiwan
eGeneral Education Center, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
fInstitute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung 402, Taiwan
Terminalia catappa L. was a popular folk medicine and has several proven biological activities including antioxidant and anti-inflammatory.
The present study investigated the effect of the extract of T. catappa leaves (TCE) on invasion and motility of tumor cells to find that TCE exerted a dose-dependent inhibitory effect on the invasion and motility of highly metastatic A549 and Lewis lung carcinoma (LLC) cells.
To further investigate the precise involvement of TCE in tumor metastasis, A549 and LLC cells were treated with TCE at various concentrations, up to 100 ėg/mL, for a specified period and results from zymography and Western blotting showed that a TCE treatment may decrease the expressions of matrix metalloproteinase-2, -9, urokinase plasminogen activator and their endogenous inhibitors, that is tissue inhibitor of metalloproteinase-2 and plasminogen activator inhibitor-1, in a concentration-dependent manner.
Furthermore, the inhibitory effect of TCE on the growth and metastasis of LLC cells in vivo was proven. These results indicated that TCE could be applied to be a potential antimetastatic agent.
Food and Chemical Toxicology
Volume 45, Issue 7, July 2007, Pages 1194-1201
Tropical almond, Singapore almond, Alemendro, Myrobalan
Fruit approximately two inches long, flattened, greenish or reddish, one seed.
Malay Penninsula, World-wide in tropical areas
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