Tamoxifen & Beneficial Interactions

February 2010:

Combining tamoxifen, the world’s most prescribed breast cancer agent, with a compound found in the flowering plant feverfew may prevent initial or future resistance to the drug, say researchers at Georgetown Lombardi Comprehensive Cancer Center. * * * * * * *

Tamoxifen May Positively Interact With Vitamins E and C

A team of researchers in India found early preliminary evidence that vitamins C and E may be helpful for women who are taking the drug tamoxifen for breast cancer. Tamoxifen is an "anti-estrogen" used in women with breast cancer. Although this drug can be quite effective, it also has the effect of raising levels of triglycerides (fat) in the blood. This, in turn, would be expected to lead to an increased risk of heart disease and strokes.

Researchers found that adding vitamin C (500mg/day) and vitamin E (400mg/day) substantially reduced triglyceride levels. In addition, the vitamins improved levels of total cholesterol, LDL ("bad") cholesterol, and HDL ("good") cholesterol. However, these results are preliminary and the study was not a double blind, placebo-controlled trial.

More rigorous clinical trials are needed to determine whether tamoxifen users really should add vitamins E and C to their diets. (See Babu JR, Sundravel S, Arumugam G, et al. Salubrious effect of vitamin C and vitamin E on tamoxifen-treated women in breast cancer with reference to plasma lipid and lipoprotein levels.

Cancer Letter 2000;151:1-5.)

Tamoxifen for Five Years

JNCI March 2001

Negative Nodes Follow-up After 7 Years (B14)
GLA and Tamoxifen May  Down-Regulate ER Pathway

Int J Cancer, May 2001

Gamma Linolenic Acid & Tamoxifen
Black Cohosh & No Proliferation of Bca Cells

Breast Can Res Tr, 11.02 Enahnces Tamoxifen

Black Cohosh Enhances Chemo Potency
Black Cohosh on Mammary Tumors in MMTV-nude Mice
Black Cohosh Linked to Autoimmune Hepatitis
Black Cohosh DOES NOT Have Estrogenic Activity
Black Cohosh Alters Effect of Chemotherapy
Black Cohosh Cuts Cancer Risks
Tamoxifen Plus Soy Prevents Bca in Rats

Presented at AACR 4/01

Genistein May Negate Tam Effect
Melatonin & Tamoxifen Good Combo

Neuroendocrinology Letters, Vol, 18, No. 1

IP6 Enhances Adriamycin & Tamoxifen (Bca)

Breast Cancer Res & Treatment, 6/03

EPA Restores Tamoxifen Sensitivity (Akt activity)

Annals of Oncology, 7/03

Flaxseed Enhances Inhibitory Effect of Tamoxifen: ER+ Bca

AACR Abstract #973, 2003

Feverfew May Reduce Resistance to Tamoxifen

Press Release Georgetown University study February 2010 in FASEB

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