ABSTRACT: Effects of Tamoxifen on the Serum Leptin Level in Patients
with Breast Cancer
Background: Leptin is a peptide hormone that has a role in the
regulation of body weight and has effects on metabolic, neuroendocrine,
reproductive and hematopoietic systems.
Breast cancer has also
been associated with obesity and reproductive hormones, especially
Only a few studies have investigated the relation
between plasma leptin and risk of breast cancer and only one
study evaluated the effect of tamoxifen on leptin levels in patients
with breast cancer.
Conclusion: High serum leptin levels seen in breast cancer patients
are not related to stage of the disease or to cancer itself but
may be associated with the use of tamoxifen.
[12/27/2001; Japanese Journal of Clinical Oncology
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