Tamoxifen Therapy for Ovarian Cancer in the Adjuvant and Advanced
Settings: Systematic Review of the Literature and Implications for
Perez-Gracia JL, Carrasco EM.
Clinical Research Department, Eli Lilly and Company, Avenida de la
Industria 30, Alcobendas, 28108, Spain
Background. Ovarian neoplasms frequently express hormonal receptors and
are sensitive to hormonal manipulations, as shown by preclinical and
However, despite the outstanding relevance of
adjuvant therapy in breast cancer and the importance of receptor status
as a predictive factor, few trials have addressed these issues in
Methods. Computerized and manual searches were performed to identify
preclinical and clinical studies evaluating single-agent tamoxifen
activity in ovarian cancer or any kind of hormonal therapy employed as
adjuvant therapy for ovarian cancer.
Results. In advanced tumors, none
of the trials was performed exclusively in chemonaive patients, but
those including less heavily pretreated patients showed greater
Some studies found a correlation between receptor status and
activity (although differences were not significant), whereas other
trials did not. Nevertheless, none were specifically designed to answer
Few randomized trials comparing hormonal treatment and
chemotherapy versus chemotherapy alone were identified.
results were negative, all were small, and none was designed with the
rigor that allowed adjuvant hormonal therapy to become successfully
established in breast cancer.
Conclusion. The activity of tamoxifen in advanced ovarian cancer has
been adequately evaluated and its role may have been underestimated.
Furthermore, the relevance of adjuvant hormonal therapy in ovarian
cancer and the predictive value of hormonal receptors have never been
studied in well-designed trials. Additional studies to clarify the role
of tamoxifen for this indication are warranted.
Gynecol Oncol 2002 Feb;84(2):201-209
PMID: 11812075 [PubMed - as supplied by
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