"Potential Application of Ganoderma Polysaccharides in 
the Immune Surveillance and Chemoprevention of Cancer"

Raymond Y. Chang, author Department of Medicine, Memorial Sloan Kettering Cancer Center and private practice. 1996 published in Mushroom Biology and Mushroom Products

Animal studies suggest that immune protection against cancer is effected primarily through cell-mediated immune mechanisms; and because Natural Killer (NK) lymphocyte functional acitivity correlates with the incidence of tumors. Ganoderma polysaccharides particularly those of a Beta 1,3 configuration have been extensively demonstrated to have broad immunopotentiating properties, including the stimulation of NK activity. Too date NO animal or human studies have been carried out using this for cancer prevention, but it is a potenially ideal agent since it has no toxicity.

NOTE: What all this means is that while there have been lots of small studies looking at the ability of this mushroom, among others, to boost the immune system, there have been NO human studies with cancer patients. Still, most of us cannot wait for this level of evidence (especially since no study has yet to begin). Mushrooms are not toxic and can be eaten or taken as pills.

See also MGN3 section for more on NK activity and Ann's Protocol (under Ann's Bio) for her story on Maitake mushrooms and tumor reduction.


PSK Study

Anticancer Res, 4/01

Anti-aromatase activity phytochemicals white button mushrooms
White Button Mushrooms Inhibit Aromatase Activity

J Nutrition, 2001

Ganoderma lucidum Kills Cancer Cells

Int J Cancer, 11/02

Biologic Activity:Ganoderma lucidum
Ganoderma lucidum: Acute & Short-term Biomarker Response
Anti-angiogenic/Inhibitory Activity Ganoderma lucidum (Reishi)
Ganoderma lucidum Inhibitory Effects Epstein-Barr
Ganoderma lucidum & Cell Proliferation (Reishi)
Leninus edodes Mushroom & Fatty Acid

J Nutr, 3/03

Extract of Mushroom (Lentinula edodes) Kills Ca Cells (Mice)
Anti-tumor Activities of Codyceps spp.

Phytother Res, 8/03

Immunomodulatory & Antitumor Effects: Cordycepts mushroom
Agaricus Blazei Murrill & Liver Function

Varoius studies

Brazilian Sun-Mushroom (Agaricus blazei) & NK activity
Polysaccharopeptide Inhibits Tumor (Coriolus versicolor)

Life Sci, 7/04

MUSHROOM Phellinus linteus works w/Doxorubicin

British J Cancer,

Posted 9/06

Phellinus linteus Induces Apoptosis in Prostate Ca Cells
(ER-)Inhibition of COX-2 & apoptosis: Antrodia camphorata

J Food and Chem Toxicology, 7/07

Antrodia camphorata is a popular folk medicine

Remember we are NOT Doctors and have NO medical training.

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