American Ginseng and Breast Cancer Therapeutic Agents

Synergistically inhibit MCF-7 Breast Cancer Cell Growth

J Surg Oncol 1999 Dec;72(4):230-9

Duda RB, Zhong Y, Navas V, Li MZ, Toy BR, Alavarez JG Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Background and Objectives American ginseng (Panax quinquefolius L.) purportedly alleviates menopause symptoms because of putative estrogenicity.

METHODS: Using a standardized American ginseng (AG) extract in MCF-7 breast cancer cells, the objectives were to evaluate the ability of AG to induce the estrogen- regulated gene pS2 by Northern blot analysis, determine the effect on cell growth using the MTT assay, and evaluate the cell cycle effects by flow cytometry.

RESULTS: AG and estradiol equivalently induced RNA expression of pS2. AG, in contrast to estradiol, caused a dose-dependent decrease in cell proliferation (P < 0.005). AG had no adverse effect on the cell cycle while estradiol significantly increased the proliferative phase (percent S-phase) and decreased the resting phase (G(0)-G(1) phase) (P < 0.005). Concurrent use of AG and breast cancer therapeutic agents resulted in a significant (P < 0.005) suppression of cell growth for most drugs evaluated. CONCLUSIONS: In vitro use of AG and breast cancer therapeutics synergistically inhibited cancer cell growth.

Copyright 1999 Wiley-Liss, Inc. PMID: 10589039, UI: 20057888

Ann's NOTE: American Ginseng (AG) was shown to be estrogenic but NOT HARMFUL. In fact by itself it had NO bad effect on the cell cycle (cancer cell). When combined with "breast cancer therapeutic agents" (currently unspecified-I will search this out), it showed strong suppression of cell growth. This seems to mean that American Ginseng enhanced the action of these therapeutic agents.


Variability in Commercial Ginseng Products

An Issue for All Dietary Supplements

Anti-Proliferating Effects of Ginsenoside on MCF-7

Int J Oncol 1999

Chemosensitization of Paclitaxel by Ginseng (Element)
Brazilian Ginseng & Mice with Thymic Lymphoma

Cancer Detection & Prevention 2000

Pfaffia paniculata (Brazilian ginseng) reduces angiogenesis mice
Am Ginseng May Improve Glucose Control

Am Diabetes Assoc, 6/03 Abstract #1676

Ginseng ingredient Induces Apoptosis: Liver Ca

Abstract #2979

C Ginseng Element & Apoptosis in Multidrug Resistant Cells
pS2 Expression Induced by Am Ginseng In MCF-7 breast cancer cells

Ann Surg Oncol 1996

Ginseng and Quality of Life

J Clin Pharm & Therap

Ginseng May Help Ease Fatigue

ASCO Press Release June 2007

Milk and Indian Ginseng for Immunity

Press release, 8/08

Radioprotective Effect of American Ginseng on Human Lymphocytes

J Alternative and Complementary Medicine, May 2010


Remember we are NOT Doctors and have NO medical training.

This site is like an Encyclopedia - there are many pages, many links on many topics.

Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.