"Caffeic Acid Phenethyl Ester (CAPE) Prevents Tumors in Min/+ Mice and Regulates p53 Function In Vitro" by A.M. Carothers, C. Chiao et al, Strang Cancer Prevention Center, NYC
CAPE is a phenolic antioxidant derived from honey bee propolis which decreased tumor formation in the mice used, by 63%. The authors then used human colon carcinoma cells (cancerous) and these showed a decrease as well.
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"Micronutrients Prevent Cancer & Delay Aging" by Bruce N. Ames
Approximately 40 micronutrients are required in the human diet. Deficiency of vitamins folic acid, B12, B6, C or E or Iron, Selenium or Zinc mimics radiation in damaging DNA by causing single and double-strand breaks or oxidative lesions, or both. The quarter of the population that eats the fewest fruits and vegetables (5 portions a day is advised) has about double the cancer rate of the quarter that eats the most. Folate deficiency has beenshown in about 10% of the U.S. population and in two small studies, nearly half of low income (mainly Afro-American) elderly and adolescents.
"Recent Preclinical Studies of Increased Calcium Intake and Inhibition of Colon Cancer" by Martin Lipkin, Harold Newmark, Strang Cancer Prevention Ctr and New York Hospital-Cornell Medical Ctr.
Increasing dietary calcium provides and example of a well-studied approach to cancer chemoprevention that has now progressed from basic measurements to clinical trials. Rationales for increasing dietary calcium include its ability to decrese irritant effects of bile acids and fatty acids on colonic epithelial cells by forming insoluble complexes of these substances in the colon; and by direct effects of calcium on epithelial cells to inhibit proliferation (growth) and induce differentiation-associated (good) properties of the cell. In preclinical studies (non-human), increasing dietary calcium has decreased colonic tumor development and growth in rodents when the tumors were induced by a variety of chemical carcinogens. Combined with Western-style diets with reduced levels of calcium and vitamin D and increased fat content, showed increased incidence of colonic precancerous lesions. Increasing calcium and vitamin D intake decreased the lesions and carcinomas (cancer). There are now randomized trials of humans who are at higher than average risk of colon cancer. EAT WHOLE FOODS and JUICE vegetables daily.
Several studies were reported at this conference on the use of calcium.
Ann's NOTE: calcium may indeed be a useful supplement in decreasing risk of colon cancer. But no patient or concerned person should only take calcium. It is critical to take a range of nutriets which is why I stress WHOLE FOODS and supplementation. Our bodies need the natural building blocks that food offers. Organic is better.
"The Calcium Polyp Prevention Study" by John Baron presented information to show that although calcium supplementation had no effect on rectal mucosal proliferation, there was a lower risk of recurrent adenomas in subjects who took calcium. Not toxicity was found and their findings indicate that" calcium supplementation can prevent colorectal adenomas, precursors of most colorectal cancers."
Calcium at 1200 MGs or more in men was associated with a 75% reduction in risk. 150 I.U. of Vitamin D was associated with a 50% reduction in incidence of colon cancer (in some studies). Other studies indicate 1200-1800 MGs and 600-800 I.U. Vitamin D3 daily.
"Update from Europe: European Trials on Dietary Supplementation for Cancer Prevention: by Guido Biasco
In 1990 estimates from 12 countires in the European community showed thata colorectal cancer was the most common malignancy. Some pilot studies (small size) showed that dietary supplementation with antioxidants, A, C, E or Omega 3 fatty acids were able to reduce cell defects of the normal rectal mucosa. Another study showed that A, C, E supplementation had a protective effect against regrowth of polyps. Folic acid or sodium butyrate also showed the ability to normalize cell growth abnormalities.
"Update from Asia: Asian Studies on Cancer Chemoprevention" by Taik-Koo Yun
In Asia, non-toxic dietary products are considered as desirabel primary prevention vehicles to conquer cancer problems. Korea- in 1978 we observed an anticarcinogenic effect with Panex ginseng C.A. Meyer extract. It was subsequently shown as a non-organ specific cancer preventive agent. The administration of red ginseng to AIDS patients showed a significant reduction in cancer incidence (done without placebo sections). Since 1997 there are placebo-controlled trials (considered the highest level of evidence) on red ginseng and rectal and gastritis patients going forward in China.
Korea-studying anti-cancer properties of chlorophyllin, biochanin A, soybean products, capsaicin (red pepper), Ganoderma lucidum (mushroom) and others.
Japan-studying green tea and synthetic acyclic retinoid (vitamin A) and caventol in human subjects. Placebo-controlled trials will be used to study dietary fibers and red ginseng extract. China-in conjunction with the National Cancer Institute (USA) is studying selenium, beta carotene and vitamin E.
Ann's NOTE: Unfortunately many of these studies again look at one element alone. I believe, along with many others, that it is the combination of useful elements that will prove the most effective.
"Sqaulene, Olive Oil and Cancer Risk: A Review and Hypothesis" by Harold Newmark
Epidemiologic studies looking at populations) of breast and pancreatic cancer have demonstrated that increased dietary intake of olive oil is associated with a small decreased risk or no increased risk of cancer despite a high overall lipid (fat) intake. It is proposed that the hgih squalene content of olive oil is a major factor in the cancer risk-reducing effect of olive oil.
"Indole-3-Carbinol: A Multifaceted Cancer Preventive Compound" by H. Leon Bradlow
Indole-3-carbinol (I3C) is a compound found in cruciferous vegetables (broccoli, cauliflower, watercress, brussel sprouts, cabbage). It has shown an ability to prevent mammary tumors in mice and rats. It also decreases cell proliferation (growth) in colonic cell lines.
A study was presented on the value of Resveratrol, a substance found in grapes that has some anti-cancer properties.
Many scientists and researchers in many studies have shown the benefit of one or another dietary element. The best way to gain protection whether to prevent cancer or to prevent recurrence has to be eating whole foods. Then you get ALL the components whether they have been identified, studied or not. EAT WHOLE FOODS, preferably Organic.
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