Short Antibiotic Course Controls Paediatric Urinary Tract Infection
A DGReview of :"Short compared with standard duration of antibiotic treatment for urinary tract infection: a systematic review of randomised controlled trials."
By Elda Hauschildt
Two to four days of oral antibiotics is as effective in eradicating paediatric urinary tract infection as is the longer standard course, Australian researchers report.
The short course of antibiotics was compared with a standard course of seven to 10 days in a meta- analysis of 10 randomised, controlled clinical trials. A total of 652 children attending outpatient and emergency departments participated in the trials.
Investigators from the Children's Hospital at Westmead in Sydney used three outcome measures in their analysis: urinary tract infection (UTI) at end of treatment, recurrent UTI and urinary pathogens resistant to the treatment antibiotic.
They found there was no significant difference in the frequency of positive urinary cultures at zero to seven days in patients treated with short and standard courses of antibiotics.
There was also no difference at 10 days to 15 months post-treatment.
The researchers note there was no difference among children in the short and standard groups for development of resistant organisms in UTIs at either the end of treatment or in recurrent UTIs.
Archives of Disease in Childhood, 2002; 87: 118-123.
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