Quercetin & Hyperthermia

Effects of the flavonoid drug Quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo

A. Asea, G. Ara, B. A. Teicher, M. A. Stevenson, S. K. Calderwood

Abstract:

Tumour hyperthermia, although potentially a powerful therapeutic agent and radiation sensitizer, is hindered by a number of considerations including inhomogeneous heating of deep seated tumours due to energy deposition and perfusion issues.

One solution is to design hyperthermia sensitizers to amplify the effects of hyperthermia, particularly at cold spots within the tumour undergoing treatment.

This study examined the use of Quercetin, a flavonoid drug shown previously to antagonize the expression of HSP72 and induce apoptosis as a sensitizer of prostate cancer growth in vivo. Quercetin dose-dependently suppressed PC-3 tumour growth in vitro and in vivo.

When combined in a treatment protocol with hyperthermia, quercetin drastically inhibited tumour growth and potently amplified the effects of hyperthermia on two prostate tumour types, PC-3 and DU-145 in vivo.

These experiments, thus, suggest the use of Quercetin as a hyperthermia sensitizer in the treatment of prostate carcinoma.

International Journal of Hyperthermia

Volume 17, Number 4 / July 1, 2001 347 - 356


Quercetin Sensitizes Cells to Hyperthermia

Intl J Hyperthermia 9-10/03

Synergistic Reversal effect quercetin & hyperthermia: doxorubicin

International Journal of Hyperthermia, January 2008

P53, Quercetin and Hyperthermia

International Journal of Hyperthermia, August 2008


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