Protective Effects of 

Topical Antoxidants (Skin)

December 2011

Interesting article on cream (Ann Fonfa says she heard of it years ago). Excuse the 'hyped' up title. Good information on eggplant/tomato/pepper-based product. Remember more antioxidants are helpful in reducing sunburn and cancer risk. See article below.

May 2010

“Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.” Photochem. Photobiol. Sci., 2010, 9, 597’ DOI: 10.1039/b9pp00130a.

Albena T. Dinkova-Kostova, Jed W. Fahey, Andrea L. Benedict, Stephanie N. Jenkins, Lingxiang Ye, Scott L. Wehage and Paul Talalay.

This comes from the lab that first looked at broccoli and broccoli sprouts (Johns Hopkins, MD)

Unprotected prolonged exposure to sunlight raises the risk of ultraviolet (UV) radiation to cause or accelerate skin aging as well as skin cancer. Albena T. Dinkova-Kostova, from Johns Hopkins University (Maryland, USA), and colleagues fed broccoli sprout extracts, high in glucoraphanin, a precursor to compounds in broccoli that have been identified as potent anti-carcinogens, to laboratory mice previously exposed to UV radiation.

The researchers found that a daily dose of 10 moles of glucoraphanin inhibited the subsequent development of skin tumors, with skin tumor incidence reduced by 25% and tumor volume by 70%.

Dr. William Grant of the Sunlight, Nutrition and Health Research Center (SUNARC), San Francisco, suggests maintaining a high dietary antioxidant status in order to guard against skin cancer. (posted 6/05)

Protective Effects of Topical Antioxidants in Humans

Dreher F, Maibach H

Curr Probl Dermatol. 2001;29:157-164

Human studies have convincingly demonstrated pronounced photoprotective effects of 'natural' and synthetic antioxidants when applied topically before UVR exposure. Particularly with respect to UVB-induced skin damage such as erythema formation, the photoprotective effects of antioxidants are significant when applied in distinct mixtures in appropriate vehicles.

Topical application of such combinations may result in a sustained antioxidant capacity of the skin, possibly due to antioxidant synergisms. And, since UVA-induced skin alterations are believed to be largely determined by oxidative processes, topical administration of antioxidants might be particularly promising.

In fact, topical application of antioxidants or antioxidant mixtures resulted in a remarkable increase in the minimal dose to induce immediate pigment darkening after UVA exposure and diminished the severity of UVA-induced photodermatoses in humans.

In conclusion, regular application of skin care products containing antioxidants may be of the utmost benefit in efficiently preparing our skin against exogenous oxidative stressors occurring during daily life. Furthermore, sunscreening agents may also benefit from combination with antioxidants resulting in increased safety and efficacy of such photoprotective products.

Green Tea & Skin Protection

Int J Oncol, 8/01

Green Tea EGCG on Mouse Skin Protective
Melanoma Issues

Articles, studies, LINKS

Patterns of Recurrence After SNLB:Cutaneous Melanoma
Curcumin & Irreversible Growth Inhibition/Apoptosis:Melanoma
Diet & Risk of Malignant Melanoma
Symptoms Pts w/cncrrnt BioChemothrpy Malign Melanoma
Toenail Arsenic Content & Cutaneous Melanoma: Iowa
Lymphedema After Complete Node Dissection: Melanoma
Gray Hair Shares Genetic Root w/Melanoma
Canavaxin (TM) for Stage IV Melanoma CANCELLED
Risk of Melanoma & Vitamin A, Coffee, Alcohol
Wasabi product Shows Action in Melanoma Cells
Antiangiogenic: Andrographis paniculata extract & andrographolide
Melanoma Can Appear in 'Hidden' Places Too
Do Sunscreens Increase Risk of Melanoma in Populations Residing at Higher Latitudes?
Dispelling myth of “benign hair sign” for melanoma
Genetic Manifestation of Melanoma Linked to Geographic Location
Topical EPA Protective of UVB (Mice)

Phtoochem Photobiol, 2001

Vitamin E  Protective

Curr Probl Dermatol, 2001

Chemoprevention w/Alpha-tocopherol & Mice
Antioxidant Effects of Extract from Leaves

Burns, 2001

Compound from Corn Lily For Skin Cancer
Oxidative Targets in the Stratum Corneum

Skin Pharmacol Appl Skin Physiol, 2001

Topical/Oral Reduces Papillomas in Mice

Toxicol Lett, 2001

Topical L-ascorbic Acid

Dermatol Surg, 2001

Topical Vitamin C Stops Basal Cell Carcinoma
Cream to Prevent Skin Cancer

Healthscout, 10/01


LINK for cream to TREAT Non-Melanoma Skin Cancers Research shown

Second Primary Cancers in Pts w/Squamous Cell Ca SKIN

British J Cancer, 12/04

Skin Cancer Info/Am Acad Of Derm.

2001 Summary

Basal Cell Ca Does Not Correlate with Most-Exposed Areas
DNA Repair Could Reduce Sunburn

Nature News Service, Dec 2001

Sun Lamps Double Risk of Some Skin Cancer

JNCI, 2/02

Tanning Associated with Optimal Vit D Status
Using Vitamin A Analogue with Interferon/chemo

J Clinical Oncology, 1/02

Lutein for Skin (Spinach & Leafy Green Vegs)

Soc for Investigative Dermatology, 5/02

Caffeine Protection from Ultraviolet RTx (mice)

National Acad of Sciences, 8/02

Photonics & Early Skin Ca Detection

Univ of Central Florida, 6/03

Homeopathy for Dermatologists

Book from Indian publishers

Various Fruits Are Protective for Skin Cancer

AACR Press Release, 10/03

Skin Cancer Abstracts

Frontiers in Cancer Prevention Research, 2003

EGCG, Chemoprevention & Skin Ca
Chemopreventive Effects Betanin: Skin Ca (Mice)
Calcium Glucorate & Skin Tumors
Ultraviolet Rad B & Perillyl Alcohol
Free-Tissue Transfer : Skin Cancer

Thanks to

Skin Cancer in Skin of Color

J Am Acad of Dermatology, 11.06

Skin Ca: Lack of Awareness in Minority Communities
Dermatology Technique not Good for Dark Skin
Skin Cancer & Melanoma Organizations

Locate their links here

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