ABSTRACT: The present and future role of bisphosphonates in the
management of patients with breast cancer
At least 25% of patients with breast cancer develop skeletal
metastases, with bone the site of disease producing the greatest
morbidity. It is apparent that the bisphosphonates present an
important component of the treatment strategy.
They are now the
treatment of choice in tumour-induced hypercalcaemia, and they
can reduce bone pain and skeletal complications such as pathological
In addition, bisphosphonates are being increasingly
evaluated in the prevention of bone metastases and to prevent
and treat cancer therapy-induced osteoporosis.
is aimed at trying to define the optimum route, dose, schedule
and type of bisphosphonate.
01/01/2002; Breast Cancer Research
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