Retinoic Acid

& Melatonin

Ann's NOTE: From Ralph Moss, PhD "Antioxidants Against Cancer", pg 103 Ten Cautionary Statements:

8. Do not take melatonin if you have leukemia or any other proliferative disease of the blood or lymph.

A report by cb:

10/99 Roy Weiner, Director, of the Tulane Cancer Center spoke on "Clinical Approaches to Breast Cancer: Translated Research" at a recent Oncology Grand Rounds

His stated objectives: *Understand the role of estrogen in the pathogenesis of breast cancer *Understand the potential of SERMs in modulating estrogen effect on breast cancer *Introduce breast cancer prevention and the role of SERMs *Introduce other "hormonal" pathways that have potential of preventing breast cancer by altering gene expression

I didn't understand all he said, but I did get this:

A Tulane researcher named Steve Hill has been studying MELATONIN and RETINOIC ACID (specifically 9-cis-retinoic acid) and their effects on ER+ bc cells and MCF7 cells(a breast cancer cell type) in vitro and in vivo with rats. He's getting very interesting positive results.

Preliminary findings: That melatonin has a negative effect on growth rate, and when melatonin and retinoic acid are used together they lead to apoptosis in culture, (apparently, adding melatonin means that you don't need as much retinoic acid), and either serious slowdown or apoptosis in vivo in rat mammary tumors.

"Steve took the model and translated to the rat mammary tumor model. All were given cancer followed with no mediation(treatment) vs. retinoic acid and /or melatonin. (?Growth rate? was) lower with retinoic acid alone, lower still with melatonin one day, retinoic acid the next, and lowest with melatonin plus retinoic acid."

The alternating regimen was gentler way, requiring less retinoic acid (the 'toxic' part).

They're bringing this to a Phase I clinical trial in the GCRC.

I asked what the criteria were for joining the clinical trial, this is the only NATURAL clinical trial I've ever heard of done by an orthodox medical school! -- but they want newly-diagnosed women who have never been treated, even with surgery.

Also, if you re-read the stuff on calcium d glucarate, that, too, seems to work synergistically with retinoic acid.

Ann's NOTE: Retinoic acid is a form of Vitamin A

Melatonin & Skin Cancer

Melatonin has cancer fighting properties in humans, may affect skin cancer too

Risk of BrCa  and Melatonin Issues

BMJ, February 2001

Urinary Melatonin Levles & BCa Risk
Combo Melatonin & Vit A Analogue (rats)

Cancer Lett, July, 2001

Tumor Prevention w9-cis-retinoic Acid/Melatonin
Melatonin & Immune System

Proceedings of Royal Soc of Londong, 11/01

Melatonin Inhibits Estrogen Receptor

Breast Cancer Res & Treatment 1/02

Melatonin: Inhibitor of Estrogen Receptor via Calmodulin
Melatonin Enhances Inhibitory Effect -Aromatase Activity
Influence of Melatonin on Glucose Tolerance & Insulin Sensitivity

Clin Endocrinol, 3/01

Melat & Colon Carcinogenesis:Rats

Carcinogenesis 8/97

Part II
Part III
Part IV
Night-Shift=Melatonin Deficiency=Colorectal Ca Risks
Melatonin & Supportive Care

Support Care Cancer, 3/02

Melat Reduces Toxicity: Chemo & Radiation

Lissoni, P et al

Study Reviews Literature on Melatonin

J Clinical Oncology, 5/02

Melatonin & Mammary Ca:Review
Melatonin & Mammary Tumors

Intl J Cancer, 12/02

Inhibitory Effect of Melatonin on Tumors (Rats)
Melatonin Slows Growth in Breast Cancer
Free-Running Circadian Rhythms/Melatonin/Blind

NEJM, 2000

Melatonin, Circadian Rhythms/Sleep
Colorectal Ca & Night Shift Work: Women

JNCI, 6/03

Inhibition of Lung, Mammary Gland & Colon Tumors w/Melatonin

AACR Abstract #5694, 2003

Melatonin in Children w/Sleep Disturbances

Pediatr Pharm, 11/03

References for Melatonin & Children
Review of Sleep & Melatonin

HHS Agency for Healthcare Res & Quality 12/04

Melatonin & Exercise: Breast Cancer Risk Reduction

Am J Epidemiology, 12/05

Low Blue Lights

LINK to company run by researchers "special glasses & lights that can improve both your sleep & your health". Helps produce Melatonin

Melatonin alleviates lung damage from Nitrogen Mustard

Toxicology Letters, September 2007

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