Environmental Issues w/Bca

5/08 The Estrogen Connection Breast Cancer and Make-up -

http://envirocancer.cornell.edu/research/endocrine/videos/makeup.cfm

Plasma organochlorine levels and the risk of breast cancer: An extended follow-up in the Nurses' Health Study.

Laden F, Hankinson SE, Wolff MS, Colditz GA, Willett WC, Speizer FE, Hunter DJ Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

The environmental organochlorines 2,2-bis(p-chlorophenyl)1,1,1,trichloroethane (DDT) and polychlorinated biphenyls (PCBs) have been implicated as potential causes of female breast cancer. We continued follow-up of our 1997 case-control study nested in the Nurses' Health Study cohort, adding 143 postmenopausal cases and controls to the original 238 pairs, and examining specific PCB congeners for the first time.

We measured plasma levels of 2,2-bis(p-chlorophenyl)ethylene (DDE), the major metabolite of DDT, and PCBs prospectively, comparing women who were diagnosed with breast cancer between 1 month and 4 years after blood collection with control women in whom breast cancer did not develop. Median concentrations of lipid-adjusted DDE, total PCBs, and PCB numbers 118, 138, 153 and 180, assessed individually, were similar among the cases and controls.

The multivariate relative risk of breast cancer for women in the highest quintile of exposure as compared with women in the lowest quintile was 0.82 for DDE (95% confidence interval [CI]: 0.49-1.37) and 0.84 for total PCBs (95% CI: 0.47-1.52), 0.69 for PCB 118 (95% CI: 0.39-1.22), 0.87 for PCB 138 (95% CI: 0.50-1.50), 0.83 for PCB 153 (95% CI: 0.47-1.48), and 0.98 for PCB 180 (95% CI: 0.55-1.75). Sub-group analyses were also performed.

Overall, our results do not support the hypothesis that exposure to DDT and PCBs increases the risk of breast cancer.

Int J Cancer 2001 Feb 15;91(4):568-74

Ann's NOTE: Many advocates/patients continue to believe that we will discover causality connections when we look at the totality of environmental exposures.


Mix of 4 Organochlorines Can Affect Human Bca Cells

Environmental Health Perspectives, April 2001

Combined Exposure to Organochlorines

Environ Health Perspect, March, 2001

Bay Area Higher than Europe/Japan
BCa Risk & Historical Exposure to Pesticides
Pesticides/Herbicides/Chem & Breast Ca

JNCI, May, 2001

Organochlorines&Bca Risk:assoc w/larger tumors
Organochlorines, P53
Plasma Concentrations of PCB & Risk of Bca
PCBs May Increase Risk of Bca
California to Study Breast Milk Contaminants
OCP Residue & Antioxidant Enzyme Activities
Estrogenic Organochlorines & Bca SURVIVAL
Pesticide Exposure & HER-2/neu Overexpression
EGME/Depakote Boost Estrogen/Progestin In Cells
216 Chemical Carinogens Connected to Breast Cancer
Women Who Work Predominantly at Night: Bca Risk

2001 article

Rotating Night Shifts & Risk of Bca in Women/Melatonin
Study on Exposure to Light at Night/Bca Risk
Electromagnetic Fields/Light at Night-Male Bca
Impaired Body Clock Speeds Tumor Growth (Mice)
Czech Republic Outlaws Excess Outdoor Light
Artificial Light & Bca Rates
Colorectal Ca & Night Shift Work: Women
Breast Cancer & Env Risk Factors Program

LINK to Cornell University site for Environmental issues

Link:  Birthplace/Residence at Menarche

Society for Epidem Research, 6/03

Electric Bedding Devices/Risk of BCa:Afri-Am Women

Am J Epidemiol, 10/03

No More Breast Cancer - UK

LINK to Environmental Issues site in UK

Breast Cancer Env Res Centers  BCERC

LINK to 7-year funded (NIEHS-NCI)

Early Environmental Exposures & Breast Cancer

Breast Cancer and Environmental Research Program www.bcerc.org

Why are early maturing girls less active?

J Social Science & Medicine, online April 2007

Envrnmntl pllutnts, diet, phys activity, body size, & breast ca

LINK to Cancer Journal article/editorial Volume 109, Issue S12, Pages 2627-2634

Bisphenol A Linked to Chemotherapy Resistance

Environmental Health Perspectives (online October 2008)


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