ABSTRACT: Can physical trauma cause breast cancer?
The objective of this study is to explore the effect of lifestyle
on the risk of invasive breast carcinoma in women aged 50-65 years.
A case-control study using a questionnaire and a semi-structured
Cases (n = 67) and controls (n = 134) were closely matched
on known risk factors for breast cancer including age, family history,
age at menarche, parity, age at first birth and menopausal status.
Controls were chosen from a pool of 5600 women who attended for
breast screening and filled in a questionnaire giving details to
allow matching with cases.
The study took place at the North Lancashire
Breast Screening Service. Women were aged 50-65 years and presented
with breast cancer or attended for breast screening. Women with
breast carcinoma were more likely to report physical trauma to the
breast in the previous 5 years than were the controls (odds ratio
(OR) 3.3, 95% confidence interval (CI) 1.3-10.8, P < 0.0001).
were no significant differences in a wide range of other lifestyle
indicators including factors relevant to social class, education,
residence, smoking and alcohol consumption. In conclusion, recall
bias is an unlikely explanation for these results in view of the
nature and severity of physical trauma.
Models of epithelial cell
generation indicate that a causal link between physical trauma and
cancer is plausible. A latent interval between cancer onset and
presentation of under 5 years is also plausible.
The most likely
explanation of the findings is that physical trauma can cause breast
[08/01/2002; European Journal of Cancer Prevention]
American Society of Breast Disease, 4/04
Abstract # 866
LINK to info on "preventive"
lymphatic breast massage w/pictures
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