Pesticides/Herbicides/Chem & Breast Ca

ABSTRACT: 1,1-Dichloro-2,2-bis-p-chlorophenyl-ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies

Background: Environmental exposure to organochlorines has been examined as a potential risk factor for breast cancer. In 1993, five large U.S. studies of women located mainly in the northeastern United States were funded to evaluate the association of levels of 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (DDE) and polychlorinated biphenyls (PCBs) in blood plasma or serum with breast cancer risk.

We present a combined analysis of these results to increase precision and to maximize statistical power to detect effect modification by other breast cancer risk factors.

Conclusions: Combined evidence does not support an association of breast cancer risk with plasma/serum concentrations of PCBs or DDE.

Exposure to these compounds, as measured in adult women, is unlikely to explain the high rates of breast cancer experienced in the northeastern United States.

[05/15/2001; Journal of the National Cancer Institute]

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