ABSTRACT: 1,1-Dichloro-2,2-bis-p-chlorophenyl-ethylene and Polychlorinated
Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies
Background: Environmental exposure to organochlorines has been
examined as a potential risk factor for breast cancer. In 1993,
five large U.S. studies of women located mainly in the northeastern
United States were funded to evaluate the association of levels
of 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (DDE) and polychlorinated
biphenyls (PCBs) in blood plasma or serum with breast cancer
We present a combined analysis of these results to increase
precision and to maximize statistical power to detect effect
modification by other breast cancer risk factors.
Conclusions: Combined evidence does not support an association of
breast cancer risk with plasma/serum concentrations of PCBs or
Exposure to these compounds, as measured in adult women,
is unlikely to explain the high rates of breast cancer
experienced in the northeastern United States.
[05/15/2001; Journal of the National Cancer Institute]
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