Pancreatic Cancer Issues

New Approach To Pancreatic Cancer With Photodynamic Therapy Gut

03/13/2002 By Harvey McConnell

Initial pilot study success using photodynamic therapy among 16 patients with inoperable pancreatic cancer justifies larger studies to quantify its efficacy, British clinicians think.

Compared with the average prognosis of six to 10 months survival, the trial by Dr Stephen Bown and colleagues at the National Medical Laser Centre, University College Hospital, London, England, led to almost 50 percent of patients with pancreatic cancer surviving for at least one year, two for two years and one for 30 months.

Worldwide, pancreatic cancer probably ranks ninth among the leading causes of cancer mortality. At specialized centers, over 10 percent may be resectable at presentation but, in larger population based studies, the number undergoing resection with curative intentcan be as low as 2.6 percent, the clinicians said.

Even after resection, median survival is only 12-18 months and no more than 10-20 percent of resected patients survive five years.

The researchers gave intravenous photosensitising agent meso-tetrahydroxyphenyl chlorin to the 16 patients, aged between 46 and 77 years. Three days later, they inserted up to six needles carrying laser fibres delivering light through the skin and directly into the tumour.

The photodynamic therapy shrank the area of viable tumour which, in most patients, had been large. Care is required for tumors invading the duodenal wall or involving the gastroduodenal artery.

There were few serious side effects. Patients were able to start eating and drinking within 48 hours, and they left hospital 10 days later. Almost all of the patients were able to spend most of their survival time at home with their families.

Dr Bown said that this is the first report of the use of photodynamic therapy to treat pancreatic cancer. The researchers conclude: "The technique may be of value for treating localized cancers in patients who are poor candidates for definitive surgery or in whom the location of the tumor makes pancreatic resection inappropriate. PDT can be used in conjunction with chemotherapy or radiotherapy.

These promising early results justify larger trials to assess PDT either as a single therapy or in combination with chemotherapy and/or radiotherapy."

GUT 2002;50:549-57.

DGR Review

Serum Cadmium Levels in Pts w/Pancreatic Ca: Egypt

AACR Abstract #6393, 2003

Cruciferous Vegetable Element, Apoptosis & Pancreatic Ca
Nutri Links to Plausible Mechanisms Underlying Panc Can

December 2002 Workshop

High Dietary Lycopene Lowers Risk of Pancreatic CA
Heavy Consumption Processed Meats Linked to Pancreatic Ca
Soft drinks (soda) & Pancreatic Cancer Risk
Physical Activity Decreases Risk:Pancreatic Ca

Int J Cancer, 2001

Tooth Loss Linked To Panc Ca in Smokers
Nutrition & Pancreatic Ca

NCI Div of Cancer Prevention info on nutrition and pancreatic ca

NCI-PanCAN Creates Tracking Map
High-vegetable Diet Linked to PROTECTION: Pancreatic Ca
Sugar/sweetened Foods & Risk of Pancreatic ca prospective study
Greater flavonol intake assocted w/reduced pancreatic ca risk
Nutrition support in pancreatitis.
Aspirin May Increase Risk of Pancreatic Ca in Women

Press Release, 10/03 Frontiers in Cancer Prevention Res

Aspirin Does NOT Reduce Pancreatic Ca Risk
Pancreatic Abstracts

Frontiers in Cancer Prevention Research, 2003 AACR

Isothiocynates:Pancreatic Ca & COX-2/NQ1 Targets
Fish Oil and Wasting (Cachexia)

Nutrition and Cancer, 2000 31 references

EPA used to stop Aspects of Cancer Cachexia
EPA Halts Cachexia Weight Loss
Fish Oil Supplementation: Advanced Cancer Pts
Cancer Cachexia & Tumor Growth Reduction-Omega 3
Omega-3 Adds Energy (Human Study)
Phase II Human Study High-dose Fish Oil & Cachexia
Fish Oil and Cachexia - During Chemo/HUMAN study
NCPB Improves Pain Relief BUT Not QoL/Survival

JAMA, 3/04

Chemotherapy Better than Radiation: Pancreatic Ca

NEJM, 3/04

Survival as Discussed at GI Symposium
Stimulation of NK cells, Pancreatic Ca w/Virulizin

Abstract # 4257 ASCO, 2004

Analysis of Treatment Outcomes in Pancreatic Ca
Pancreatic Cancer Groups

LINKs to advocacy, support, information (Includes information on Nicholas Gonzalez, MD and nutritional approaches)

Pt w/Pancreatic Ca and Alternative Treatments

Integrative Cancer Therapies, 3/06

Vitamin D Reduces Pancreatic Cancer Risk

Cancer Epid Biomarkers & Prevention 9/06

Complementary Approach to Pancreatic Cancer protocol, posted 9/06


Various articles and LINKS

GONZALEZ: Meeting Report by Marilyn Holasek Lloyd
Information on Dr. William D. Kelley
Dr. Jack Taylor Uses Metabolic Program
Discussion of Trial and Barriers to Recruitment
Pancreatic Enzyme Extract Improves Survival: Pancreatic
Dr.Gonzalez at 2008 BoulderFest
Small, asymptomatic neuroendocrine pancreatic tumours

J Endocrine-Related Cancer, 12/06

Press Release: Rash in Cancer Pts treated w/erlotinib (Tarceva)

July 3, 2007 American Association for Cancer Researchers

Tarceva Gets Safety Warnings - SERIOUS
Triptolide Induces Pancreatic Cancer Cell Death

Cancer Res, October 2007

Phase II Trial Curcumin - Patients w/Advanced Pancreatic Ca

Clin Cancer Res, 2008

ALA/N (alpha-lipoic acid/low-dose naltrexone) for PanCan

Integr Cancer Ther. 2009 Dec;8(4):416-22.

Jefferson Thomas, Pancreatic Cancer

New York Times, September 2010

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