Patient metabolism/nutrition critical factors:prostate ca initiation & tumor growth

Information from the Prostate Cancer Foundation November 2007 NewsPulse:

Patient metabolism and nutrition are critical factors in prostate cancer initiation and tumor growth.

Inflammation and inflammatory cells inside the prostate are involved in driving prostate cancer growth.

Similarly, inflammation around metastatic prostate cancers may fuel their growth as well.

Diets that provide less "fuel" for inflammatory cells in the prostate and that reduce the presence of pro-inflammatory free oxygen radicals, appear to increase life expectancy in prostate cancer animal models.

Further PCF research is underway on the ideal "anti-inflammatory diet" -- with a focus on developing specific recommendations for men who have been diagnosed with prostate cancer, as well as recommendations for families with histories of prostate cancer who want to lower their risk of developing the disease.

In metabolism research, more evidence exists that specific hormones released by fat cells might promote prostate cancer cell survival. In fact, abdominal fat might be a particularly large source of these growth factors for cancer cells.

Fat, it turns out, is not just insulation, but can work as a hormone-producing organ. Furthermore, food preparation could affect lifetime prostate cancer risk. A major dietary cancer-causing chemical (carcinogen) called PhiP accumulates in the prostate upon ingestion of charred red meats, fish, or chicken.

Of interest to epidemiologists are the far lower rates of prostate cancer in Asia, and the relative absence of charred meat in Asia, compared to American and European cuisine.

Implications: Further research and research support is needed on scientific metabolic parameters and dietary recommendations for each prostate cancer patient. Research on fat cells, lifestyle choices, and exercise programs are all now warranted.

Evidence in animal models suggests that PhiPs need to be reduced or eliminated from the human diet by preparation of meat that does not involve charring.

From an email sent by Ann Fonfa, President of The Annie Appleseed Project to the Prostate Cancer Foundation 11/29/07

Every study ends with a call for more research. Are you willing to support a call right now for prostate health to start with a healthy diet - defined as lots of fruits and vegetables, less red meat, less sugar, less salt, no soda, no deep-fried foods, and absolutely no 'JUNK' food?

That would be a good immediate message while we wait the many, many years needed to fully research any question.

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