Some Warning Signs You and Your Doctor Should

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FDA News:

New Safety Concerns On ESAs Prompt FDA To Consult ODAC

By Paul Goldberg

The Cancer Letter, volume 34, no 1

On Dec. 4, 2007 Amgen informed FDA of the results of a study by the NCI Gynecologic Oncology Group of chemotherapy and radiation for advanced cervical cancer. The patients were administered either Procrit, a drug licensed to Johnson & Johnson, to maintain hemoglobin levels above 12 g/dL, or blood transfusions as needed. After three years, 66 percent of the patients who did not take Procrit were alive and free of cancer growth, compared to 58 percent who had received the drug. The study closed prematurely with less than 25 percent of planned enrollment, because of concerns about thromboembolic events.

Both studies sought to increase hemoglobin above12 g/dL, the upper limit noted on the ESA label.

12/12/06 email from advocate:

I just wanted to tell people that you can change things in the medical community. The "Silent Killer" nomenclature associated with ovarian cancer has been slayed. It's taken a long time and a lot of effort. Cindy Melancon, one of our ocers worked with Barbara Goff, a gyn/onc from Seattle to start the research that has led to this.

Unfortunately Cindy died from ovarian cancer in June of 2002 but her legacy lives on in the continuing support her newsletter, Conversations, gives to women diagnosed with oc. However, the survey that Cindy sent out in her newsletter (where 200 more copies were returned than were sent out) on symptoms women experienced before diagnosis, led to the research that has now resulted in a CME on Ovarian Cancer Symptoms.

I can't begin to tell you all how much this means to our community and wanted to share this accomplishment so you'll know we can make a difference.

Diane (email 12/21/06)

From MEDSCAPE: Early detection of ovarian cancer is possible through an evaluation of specific symptoms of recent onset and significant frequency, according to the results of a case-control study reported in the December 11 Early View issue of Cancer.

When your symptoms are persistent and other explanations don't work, make sure you and your doctor know the following:

Ovarian Cancer Facts:

Occurs in 1 out of 55 women, at any age

Most women are diagnosed when the chance of survival for 5 years is about 20%. Early detection improves survival rate Ann's NOTE: A blood test LPA is currently being tested that may truly be able to detect very early (Stage 1) ovarian cancer. It is in clinical trial now. And remember, some women survive in every group.

Symptoms are subtle, persistent and usually increase over time: bloating, a feeling of fullness, gas frequent or urgent urination nausea, indigestion, constipation, diarrhea, menstrual disorders, pain during intercourse fatigue, backaches

TAKE ACTION If any symptoms last more than 2-3 weeks .Ask for a comgination pelvic/rectal exam, a CA 125 blood test and a transvaginal sonogram.

UPDATE: 6/04 (Source: - part of physician continuing education)

Of 1,709 women who visited two primary care clinics and completed an anonymous survey of symptoms experienced for the past year (July 2001 to January 2002), 128 women had ovarian masses.

In the overall clinic population, 72% reported recurring symptoms with a median number of two symptoms; 45% had back pain, 34% had fatigue, 27% had bloating, 24% had constipation, 22% had abdominal pain, and 16% had urinary symptoms.

Compared with controls, ovarian cancer cases had significantly increased odds ratios for increased abdominal size (7.4), bloating (3.6), urinary urgency (2.5), and pelvic pain (2.2). Compared with women with benign masses or with controls, women with ovarian cancer had significantly more symptoms of higher severity and more recent onset, and they typically experienced symptoms 20 to 30 times per month. The symptom pattern of bloating, increased abdominal size, and urinary symptoms was reported by 43% of women with ovarian cancer but by only 8% of the overall primary care clinic population.

"While our current study did find that women who present to primary care clinics frequently have vague symptoms that can be associated with ovarian cancer, the important difference is that these symptoms are less severe and less frequent when compared with women with ovarian cancer," the authors write. "Women with ovarian cancer typically have symptoms of recent onset and have multiple symptoms that coexist. This study adds further evidence that ovarian cancer is not a silent disease."

The Ovarian Cancer Research Fund, Inc., supported this study.

JAMA. 2004;291:2705-2712, 2755-2756

A Pap smear is NOT an effective detection method for ovarian, it is for cervical. See below for an effective test-HPV DNA for cervical cancer.

Uterine cancer (endometrial cancer)' most prominent symptom is unexpected/irregular vaginal bleeding.

From: The Ovarian Cancer National Alliance, 1627 K Street NW, 12th Fl. Washington, D.C. 20006 (202) 331-1332

DO NOT USE TALC (Talcum) POWDER GENITALLY. This is a known risk factor. Studies have identified the use of talc as contributing factor to ovarian cancer. You can use cornstarch as a substitute.

Take a look at MAMM Magazine which features articles about ovarian, cervical, endometrial, breast cancers and more.

(special sections on Lesbian Health Issues and Women with Different Abilities are found on the Breast Cancer Issues page)

12/05 Using Intrperitoneal Cisplatin and Paclitaxel was life extending but the unwanted ('side') effects are very strong. There are many bits of information on this site on how to reduce effects from chemotherapy. Please think about combining/integrating them. Speak to your physican, download articles from this site to help open a dialogue.


Symptoms Identified : Ovarian Cancer

Obstet Gynecol 7/01

Activist Letter
Recommendation: Routine Screening/Ovarian Ca
Misdiagnosis w/Ova & GI Cancers
Symptoms Presented Ova Ca:Primary Care Clinics
Ovarian Ca Cells Alter to Resist Chemo
Ovarian Ca Survivors Views on Cause/Prevention/Recurrence
Ova Sex Cord-Stromal Tumors
Lycopene May Reduce Fibroid Tumors
Ovarian Ca Surgery - Volume by Surgeon MATTERS
Excess Risk of Ovarian Ca & Lymphoma
Serum IGF-I & Epithelial Ovarian Cancer Risk: Under 55
National Consensus 2007 (OCNA Statement)
Septated Cystic Ovarian tumors LOW RISK of CANCER
REMOVE Fallopian Tubes:Prevent Ovarian Cancer
Lymphedema in GYN & Prostate malignancies

Occurs after surgery and radiation therapy for many cancers.

Lower Limb Lymphedema
Inflatable Plastic Wedge
Bandages, Sleeves, Stockings, Etc.
LE Treatments Underutilized
Hereditary Factors-BRCA1/BRCA 2/OTHERS

Survival and other information

Family connections
Breast-feeding & Risk Reduction BRCA1/BRCA2
Breast Imaging Study for Those w/Genetic Risk
Increased Sensitivity in Testing
Hereditary Ovarian Cancer & Survival
Prophylactic Surgery to Reduce Risk of GYN Lynch Syndrome
Study: Lumpectomies Work Well
Risk of Contralateral Bca
Exercise May Delay Onset of Cancer
Oral Contraceptives & Bca/Ovca
Excerpts:Intl Conf Adj Breast Therapy
Non Profit Org for Those Affected by Hereditary Br/OVA Ca
Lifetime Risks Bca:Ashkenazi Jewish Carriers
Prophylactic Bilateral Mastectomy
Familial Risk Raised by Alcohol (Bca)
Survival Rates
Most w/Family History Do Not Get Cancer
BRCA 1 Does More in Ovarian Ca
BRCA Mutations & Improved Ova CA Survival
New Guidelines: Testing Hereditary Colorecal Ca/Other Ca Risks
New Breast Cancer Gene Found-CHEK2
Risk of BCA: w/ Malignant Melanoma
ATM Mutations in Bca/Oca
Race & Attitudes on Genetic Testing
Complementary Medicine & Genetic Testing
New Method to Prevent/Treat Hereditary BCa -Sweden
Non-BRCA Hereditary Breast Ca & New Cancers
Chest X-rays & Risk of BCa: BRCA1/2 Mutations Carriers
Diagnostic/Screening Tests

This may be a way to get an early diagnosis

Update May/June 1999
Update May 2000
Blood tests 2002
Experimental Blood Test:Uterine & Ovarian
LPA : Another Point of View (Study)
Protasin Possible Biomarker for Ovarian Cancer
Photodynamic Diagnosis of Ovarian Ca
HE4 Molecule for Diagnostics
Ultrasound with Power Doppler
Ova Ca Found:Contrast-enhanced Power Doppler Ultrasound
Lysophospholipids as Biomarkers: Ova Ca (LPA)
New Blood Test for Ovarian Cancer
Six-Marker Panel Detects Ovarian Ca
To buy books from

Through Women's Cancer Network, they benefit and so does the Gynecologic Cancer Foundation

Ovarian-tumor Index

Surgery may be avoided if benign determination can be made with this method

Test Using Folate

May help with earlier detection

Genetic Analysis of Early/Late Stage Ovarian Tumors

Cancer Research 8/01

Cervical Cancer Issues

Studies, articles, issues

Cancer Early Detection Program
HPV DNA Test & Vaccine Info
Oral Beta-Carotene & High Grade Cervical Neoplasia
Sentinel Node in Cervical Cancer
2001 Bethesda System-Reporting Pap Abnormalities
Fam Docs' & Risk Factors:Cervical Ca
Vinegar To Detect Cervical Cancer
Protective Effects:Green Tea & Cervical Lesions
Outcomes/Prognostic Factors:Cervical & RTx
Post-treatment Sexual Adjust:Cervi/Endo Ca
Pap Smears Every Three Years
Indole-3-Carbinol and Cervical Dysplasia
Antioxidants and Cervical Cancer
SNB in Cervical Ca
Patient Story - Facing Cancer on My Own
Effect of Preemptive Epidural Analgesia
Pau D'Arco and Taxol

Animal Study in ovarian cancer- tumor cells destroyed completely

Preserving Fertility Not a Survival Threat

Study presented at Society of Gynecologists 2000 Annual Meeting, and more

Cervical Ca Patients May NOT Need Hysterectomies
Tubal Ligation Cuts Risk of Ovarian CA (in High-risk Women)
Fertility Preserved w/Tissue Implant to Arms
Conservative Surgery for Ova Tumors/Preserves Fertility
Frozen Rat Ovaries and Fertility
Cancer Incidence in Women who had in vitro Fertilization
Surgeons in China Do Whole Ovary Transplant
Prolonged Lactation Reduces Ova Ca Risk (China)
Ovarian Tissue Transplantation Works Despite Genetic Differences
Exercise Reduces Ovarian Cancer Risk

Study: Obstetrics and Gynecology Journal 10/00

Study of Recreational Physical Activity:Ovarian Ca
Moderate Exercise May Lower Risk (Ova Ca)
Alcoholic Women & Ova Ca

Study from Sweden, Int'l Journal of Cancer

Long Term Estrogen Use & Ovarian Ca

JAMA, March 2001

Oral Contraceptives Do Not Reduce Ovarian Ca Risk
Estrogen Replacement Therapy & Ova Ca Mortality
HRT & Risk of Ovarian Cancer
Hyperthermia  In Gyn Cancers

Eur J Cancer, 7/01

Liposomal Doxorubicin & Local Hyperthermia
Neoadjuvant Chemo/Hyperthermia
Hyperthermia Boosts Remission in Cervical Ca
Ovarian Groups w/ Links

Many different groups, sites

Resilience, Reflection & Residual Stress-Ovarian Survivorship
Support May Reduce Ca Growth Factor
Red Meat & Increased Ova Ca Risk

Int J of Cancer, 9/01

Ralph Moss' Take on this Study
Glove Powder Aids Growth

Br J Surg, 2001

Perineal Talc Exposure & Epithelial Ovarian Ca Risk
Talc Use Linked to Ovarian Cancer Risk
Angiogenesis in Ovarian/Breast Ca

Cancer Lett, 9/01

Vaginal Dilators:  Resolve Problems post RTX

Two companies that offers products to help

Preventing Vaginal Stenosis
Product to Help with Vaginal Dryness
Gyn Surgery

Obstet Gynecol,12/01

Acupressure Bands Vs. Droperidol Nausea
SystLymphadenectomy vs. Opti Debulking: Same Survival
Venous thromboembolism prevention: GYN surgery
Ginger in prevention of nausea/vomiting after major GYN surgery
Advantages to Chemo BEFORE Surgery in Ova Ca
Carbon Dxde & Human OvaCa Cell Growth

Am J Obstetrics and Gynecology, 12/01

Inhibition of Ca Cells by Artemisinin Derivatives
Scutellaria barbatae & Ovarian Ca cells
Cancer Metastases & Signal in cells

Cell, 1/02

Epithelial Ova Cancer Metastases to the Brain
U.S. Women NOT Best GYN Cancer Care

Cancer J, 11-12/01

Comparison of CAM use by Gyn & Gyn Onc Patients
Australian Women's Explanations of Gynecological Cancers
Tamoxifen for Ovarian Cancer

Gynecol Oncol, 2/02

Risk for Other Cancers After Gyn Cancer

Ann Intern Med,8/99

Skewed X chromosome:Ova/Breast
Women with Colorectal and Endometrial Cancer
Chemotherapy Issues

JNCI, 1/15/03

12-cycle Chemo Offers DF Advantage-Not OS
More than 3 Cycles May Not Reduce Recurrence Risk
CA125 Criteria Overestimates Response:2nd Line
Mucinous Epithelial Ova Ca: Not Responsive
Glutathione Reduced Toxicity for Cisplatin:Ova Ca
Trial of Phenoxodiol as Chemo-Sensitizer
Update on "Sindbis Vector Extended Life in Mouse Model
Pre-Taxol Era & Ova Ca Assays
Squalamine & Cisplatin Enhanced Activity
16 Month Survival Advantage w/Intraperitoneal Chemo (Toxicity)
Cranberries May Improve Chemotherapy for Ovarian Cancer
Center for Disease Control-DES info


Stats on Carcinosarcoma of the Ovary

BR J Cancer, 3/03

QOL in Ovarian Cancer Survivors
Communication on Sexual Issues w/docs

Br J Cancer, 3/03 Ovarian ca Survivors

Product to Help with Vaginal Dryness
Predictors of Sexual Functioning in Ova Ca Pts
"OvaCa Your Guide to Taking Control" BOOK

Thanks to Diane Paul

Cindy Francine Hills Melancon, an OBIT

Amarillo Globe-News, June 8, 2003

Leslie Revsin, Trailblazer as a Chef, Dies at 59
OBIT: Carlene Lewis, Lawyer Fought Vioxx
OBIT: Michele Maxian, 55, Dies; Won Shorter Lockup Times
Doris Dungey, Prescient Finance Blogger, Dies at 47
Sean Patrick , Founder Hera Foundation
Evelyn Virginia MacMahon Ackerman - July 30, 2010 Ovarian Ca
Susan Butler, Founding Member Ovarian Cancer Nat'l Alliance
COX-2 Expression in Ova & Endo Ca

Am J Obstet Gynecol., 6/03

Gene Suppresses Ova Tumor Growth

Nature Genetics

Ovarian Cancer Abstracts

Frontiers in Cancer Prevention Research, 2003

Alcohol, Wine & Risk of Ova Ca
Tampa Bay Ovarian Ca Study:BRCA1/2
Routine Follow-up Useful After Vulva Carcinoma

Cancer, 12/03

Endometrial Issues

Variety of Studies/Concerns

Treatment for Endometriosis=Ovarian Cancer Risk
EndomThickness Measured w/Trans-Vag Sono
Endo Carcinoma Suveillance-Ultrasound Scan Results
Vaginal Brachytherapy for Endometrial Ca
Dietary factors & Endometrial Ca
Outpatient Laser by MRI for Fibroids
Surveillance for Endometrial Ca-Transvaginal Sono-Tamoxifen
Inherited Susceptibility to Endo CA
Endo Ca After RTx for Cervical Ca
Lymph Node Removal Sometimes Unnecessary:Endo Ca
Endometrial Ca Rates Lower in Greece
African American Women Have Worse Endometrial CA Profiles
Herceptin May Be Useful with Endometrial CA Mets
Younger Women with Endo Ca can keep Ovaries Safely
Antiproliferative Effects (Cruciferous Vegs) Ova Ca

Abstract #5194 AACR, 2005

Resveratrol Induces Type II cell death Ovarian Ca
Sulforaphane (Broccoli extract) Anti Proliferative Ova Ca
Chinese Herb (isolated drug) Enhances Cisplatin Ova Ca
Vitamin E analog Induces Cell Death/Sensitizes to Cisplatin Ova
Epidem/Biological Evidence Ginkgo biloba & Ova Ca
Genistein (Soy) Inhibits Glucose Uptake, Causes Cell Death Ova
Omega-3 Fatty Acids Induce TGF-beta Ova Ca
Glutathione Analog Prodrug Resensitizes to Carboplatin Ova
Oliogosaccharides as Anti-Angiogenic Agents Ova Ca
PABA Enhances in vitro Tumor Response Ova Ca Topotecan
Effect of Anserine (food) Enhances Chemo
Cachexia, Oxidative Stress, Antioxidants, Pharmaco-nutrition Ova
Ovarian Cancer: Patient Perspective

J.A. used mushrooms to deal with her adenocarcinoma, 2/04

Nutrients & Food Groups/Risk of Ova Ca/SURVIVAL

Nutrition and Cancer, 2001

Case-Control: Carotenoid/Vit A & Ovarian Ca
Dietary Antioxidants, Supplements & Risk of Epithelial Ova Ca
Retinoids (synthetic Vitamin A)
Fructooligarsaccharides/Isoflavone Conjugates:Bone Density
Risks of Ovarian Ca Related to Dietary Intake
Citrus Flavinoids & Prev of Lifestyle-Related Bone/Lipids
Green Tea ENHANCES SURVIVAL Epithelial Ova Ca
Resveratrol Inhibited Growth/Induced Death: Ova Ca Cells
Soybean Trypsin Inhibitor 4 Mets -Mice Ova Ca
Squalamine & Cisplatin: Therapeutic Agents Ovarian Ca
Ovarian Ca Risk From Milk Products Increases
Use of Antioxidants w/1st Line Chemo in Ovarian Ca (2 cases)
Flaxseeds Increase Ovarian Survival (hens)
OvarCa Risk & Exposure: Diesel Exhaust

Intl J Cancer, 4/04 online

Nutritional Intervention RTx & Pelvic Malignancy-NEEDS STUDY

Br J Cancer, 5/04

Canadian Activist, Ontario on Health Issues

Letter Sent to the Toronto Star July, 2005

Sandi Pniauskas Letter, October 2005
Transcervical  Biopsy - Uterine Sarcoma/Benign Leiomyoma


Metastatic Uterine Sarcoma:Review of Literature
Ginseng and Quality of Life

J Clin Pharm & Therap

Observatoire Francophone des Tumeurs Malignes Rares de l'Ovaire


Remember we are NOT Doctors and have NO medical training.

This site is like an Encyclopedia - there are many pages, many links on many topics.

Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.