Outcomes/Prognostic Factors:Cervical & RTx

Therapeutic outcome and prognostic factors in the radiotherapy of recurrences of cervical carcinoma following surgery.

Hille A, Weiss E, Hess CF.

Department of Radiotherapy, University of Gottingen, Germany. a.hille@med.uni-goettingen.de

PURPOSE: To evaluate the efficacy of radiotherapy in patients with recurrences of cervical carcinoma.

PATIENTS AND METHODS: 26 patients who underwent radiation therapy for recurrences of cervical carcinoma following surgery between 1989 and 1999 were retrospectively analyzed. 17 patients had inoperable or macroscopic residual tumor.

Nine patients had a complete/microscopically incomplete tumor resection. Depending on tumor burden and location of the recurrence, external beam radiotherapy or a combination with brachytherapy was delivered to a total dose of 50-65 Gy.

RESULTS: The 5-year overall survival was 28%, relapse-free survival 24%, pelvic control 48%. Therapeutic outcome was related to the margins of resection, location of recurrence and technique of radiotherapy.

In case of surgery without residual or microscopic tumor, the 5-year survival rate was 67%, with macroscopic tumor no patient was alive after 37 months (p = 0.05). 5-year overall survival was 42% for central recurrences, 10% for recurrences with pelvic wall infiltration.

Recurrences confined to the vagina or paravaginal tissue had a higher 5-year overall probability as compared to all other patients (57% vs. 14%).

All patients treated with combined radiotherapy were alive, whereas all patients treated only with external radiotherapy were dead after 32 months (p = 0.01).

CONCLUSION: The probability of controlling recurrence mostly depends on a small tumor burden with the possibility of brachytherapy and/or complete surgery. Aggressive treatment modalities like radiochemotherapy and/or higher radiation doses are needed, especially for recurrences with infiltration of the pelvic wall and/or with macroscopic tumor.

Strahlenther Onkol. 2003 Nov;179(11):742-7.

Long Risk of Second Cancers After Radiotherapy for Cervical Ca

Int J Rad Onc, Bio, Phys, 11/07

Cancer Risk Endures 25 Years After Treatment for Cervical Dysplasia

BMJ, October 2007

Remember we are NOT Doctors and have NO medical training.

This site is like an Encyclopedia - there are many pages, many links on many topics.

Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.