Oral Contraceptives &  Bca/Ovca

Risk of Breast Cancer With Oral Contraceptive Use in Women With a Family History of Breast CancerContext:


Oral contraceptive (OC) use is weakly associated with breast cancer risk in the general population, but the association among women with a familial predisposition to breast cancer is less clear.

Objective: To determine whether the association between OC use and risk of breast cancer is influenced by family history of the disease.

Conclusions: These results suggest that women who have ever used earlier formulations of OCs and who also have a first-degree relative with breast cancer may be at particularly high risk for breast cancer. Further studies of women with a strong family history who have used more recent lower-dosage formulations of OCs are needed to determine how women with a familial predisposition to breast cancer should be advised regarding OC use today.

JAMA. 2000;284:1791-1798

Oral Contraceptives Do Not Reduce Ovarian Ca Risk

NE J of Medicine, 2001

Pill Hormone & Lower Ovarian Risk

JNCI, 1/02

Progesterone and cell death

In vitro use kills cancer cells

Oral Contraceptibes Not Linked to Breast Cancer

Medscape take on NEJM, 2002

Contraceptive/Repro History & Ova Ca Risk

Am J Epidemiology, 9/04

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