Risk of Breast Cancer With Oral Contraceptive Use in Women With a Family History of Breast CancerContext:
Oral contraceptive (OC) use is weakly associated with breast
cancer risk in the general population, but the association among
women with a familial predisposition to breast cancer is less
Objective: To determine whether the association between OC
use and risk of breast cancer is influenced by family history
of the disease.
Conclusions: These results suggest that women who have ever used earlier
formulations of OCs and who also have a first-degree relative with breast
cancer may be at particularly high risk for breast cancer. Further
studies of women with a strong family history who have used more
recent lower-dosage formulations of OCs are needed to determine
how women with a familial predisposition to breast cancer should
be advised regarding OC use today.
NE J of Medicine, 2001
In vitro use kills cancer cells
Medscape take on NEJM, 2002
Am J Epidemiology, 9/04
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