Lung Cancer Information (including Mesothelioma )

April 2009

In a study in Critical Care (March 2009)

Dr. Licker of the University of Geneva and colleagues noted that a protocol involving the use of low tidal volume, limitation of maximal pressure ventilation and the addition of end-expiratory positive pressure along with recruitment maneuvers considerably reduced the risk of the development of an acute lung injury syndrome. More complete report below.

November 1, 2008

The Cochrane Library contains many reviews and meta-analyses of important studies. It is a vast resource of great value to people seeking to find out what really works in a given medical situation. The Cochrane Collaboration is a world-wide volunteer network with very high standards that ALL involved must follow.

There is a Lung Cancer Collaborative Review Group - here is their website:

February 2008:

A comparison of three methods of minimally invasive endoscopic staging found that ultrasound-guided endobronchial and transesophageal fine-needle aspiration, or a combination, provided accurate staging of the mediastinum, Michael B. Wallace, M.D., of the Mayo Clinic here, and colleagues reported in the Feb. 6 issue of the Journal of the American Medical Association.

Journal of the American Medical Association Source reference: Wallace M, et al "Minimally invasive endoscopic staging of suspected lung cancer" JAMA 2008; 299: 540-546.

Use of Genistein Helps Cancer Cells Die

Non Small Cell

p53-Independent Apoptosis Induced by Genistein in Lung Cancer Cells Fangru Lian, Yiwei Li, Mahbubur Bhuiyan, Fazlul H. Sarkar.

Lung cancer is the leading cause of cancer-related deaths in the world, with increasing incidence in many developed countries. Epidemiological data suggest that consumption of soy products may be associated with a decreased risk of cancer. Despite the association of nutrition and cancer, the molecular mechanisms by which the active metabolite in the soy diet, genistein, exerts its biological response have not been studied.

We previously showed that genistein can inhibit the growth of H460 non-small-cell lung cancer (NSCLC) cells in vitro. To explore the molecular mechanisms by which genistein inhibits the growth of NSCLC cells, we investigated cell growth inhibition, modulation in gene expression, and induction of apoptosis by genistein in H460 cells, which harbor wild-type p53, and H322 cells, which possess mutated p53.

Genistein was found to inhibit H460 and H322 cell growth in a dose-dependent manner. Staining with 4,6-diamidino-2-phenylindole, poly(ADP-ribose) polymerase cleavage, and flow cytometric apoptosis analysis were used to investigate apoptotic cell death, and the results show that 30 M genistein causes cell death via a typical apoptotic pathway. Western blot analysis demonstrated upregulations of p21WAF1 and Bax by genistein in wild-type and mutant p53 cell lines.

Furthermore, cells treated with genistein showed an increased expression of endogenous wild-type p53, while the level of the mutant p53 protein remained unchanged. From these results, we conclude that genistein induces apoptosis in NSCLC cells through a p53-independent pathway and, thus, may act as an anticancer agent. [Nutrition and Cancer 33(2):125-131, 1999. 1999 Lawrence Erlbaum Associates, Inc.]

Ann's NOTE: These researchers have found that genistein is causing NSCLC cells to die. This is what we want. They do not know why. They suggest more study. Here is where patients interested in alternative therapies take a leap of faith. I would start using GENISTEIN, in fact I would use SOY in its natural form as well.

It could be years before scientists work out why. As a patient, we cannot care about that as much as the results.

NO Benefit for Adjuvant Chemo in NSCLC BUT...

Hem/Onc News, 1/04

Who to Treat NSCLC
Menopausal status of women may affect survival in adv NSCLC
Information about Adjuvant Cisplatin
Isotretinoin (retinoid, Vit A deriv) Not Helpful w/smokers

JNCI, April, 2001

Beta-Carotene Alters Morphology of Small Cell Lung Ca Cells
Chemoprevention & NSCLC
Lung Cancer: Studies and Issues

Surgery results

Equal Survival:Shorter Chemo Course
Influence of Hospital Volume on Survival After Resection
RadioFrequency Ablation Surgery
Herbal Medicine
Risk of Death & Postop Radiotherapy
CT Scanning: Lung CA
Iressa:Cause of Death in Lung Cancer Patients
Celecoxib, Medroxyprogesterone, Dietary :Lung Ca
PET Shows Radiation-induced Changes to Lungs
Risk factors for acute esophagitis: Non-small cell Lung Ca
-9 Tetrahydrocannabinol inhibits growth & metastasis of lung cancer
Fruit/Veg & Lung Cancer Risks

Journal of National Cancer Institute 11/00

Randomized Trial Using Organosulfur Compound
Eating More Vitamin A-rich Vegetables May Reduce the Risk of Lung Cancer
Diet as Risk for Lung Ca: Sweden
Dietary Cryptoxanthin & Reduced Risk Lung Ca
High Dietary Fiber Reduces Cough w/Phlegm
Type of Wine and Risk of Lung Cancer
Plasma/Lung Macrophage Responds: Carotenoid Supplmts
Vitamin E
Risk of Lung Ca in Relatives of Patients w/Early Onset
Lung Cancer & Phytoestrogens (Plant-derived compounds)
Cruciferous Vegetables & Lung Cancer Pts
Fruit & VegConsumption & Risk of Lung Cancer
Lung Cancer Abstracts

varied abstracts, ASCO 2004

Resection/Survival Same for Afr-Amer: NSCLC
Diabetes: Protective Against Metastasis NSCLC
Docetaxel & Glutathione Analog: NSCLC
Pemetrexed vs Docetaxel:Vitam B12/Folic Acid Added
Safety/Efficacy DHA - Paclitaxel NSCLC
Trends in Chemo Use/Survival: Metastatic NSCLC
Lung Ca & Mesothelioma Screening w/Low-dose Spiral CT
Insomnia & Lung Cancer Symptoms
Phase II Fenretinide & Small Cell Lung Ca
Gender Diff in Predictive Prognostic Factors: NSCLC
Esophagitis & Pneumonitis: Stage IIIA/B NSCLC
Oral Bexarotene w/Chemo NSCLC
Mutagen Sensitivity & Amifostine NSCLC
Smoking Issues

Various articles

Smoking Associated with ER (-) Bca
Smoking and Reconstruction Risk
Lung Ca Risk w/ Breast Ca Smokers
New Link Between Smoking and Cancer
P53 Mutations Associates w/Smoking
Exercise Does NOT Protect Smokers From Cancer
Smoking in Teens Increases Risk of Bca
Selenium's Protective Effect in Ex-Smokers
Smoking & Plasma Antioxidants
Familial Risk Lung Ca Reduced w/Folate & Vit B6
Smoking May Spread Cancer
Vit C Supplement Decreases Risk in NonSmokers
Green Tea:Prevent Oral Ca in Smokers
Secondhand Smoke
Lower Rate of Smoking in Female Lung Ca Pts
Non-Hodgkin's L & Type of Tobacco Smoke
Smoking Cessation:Cancer Survivors
Philip Morris' Methods 2 Discredit EPA Rprt:Secondhand Smoke
Beta-Carotene & Smokers (After Use)
Cigarette Manufacturers Target Women
NO Long-term Weight Gain After Quitting Smoking
Smoking, Cancer Deaths & Asian-Americans
Lung Cancer & Early Detection

A study in CHEST June 13, 2000

Chest X-Rays Do Not Save Lives(screening)
Electronic Device & Scent of Lung Cancer
Exhaled Breath Possible for Lung Cancer Detection
Lung Ca Risk w/ Breast Ca  Smokers

Chest, J of Am College of Chest Physicians, June, 2001

Vitamin E and C Synergistic w/Beta-carotene in Smokers
Lung CA Risk Higher W/Previous BCA
Carrots/Tomatoes For Prevention

Am J Cancer Nutrition, 2001 Review

Dietary Isothiocyanates, Lung Ca Among Chinese Women
Chronic Obstructive Pulmonary Disease & Nutrients
Dietary Soy Protective for Nonsmoking Women
Dietary Supplements in Lung Cancer

Nutrition & Cancer, 2001

Silibinin on Growth/Progression of Primary Lung Tumors (Mice)
Basic information and therapies to consider
Prevention acute Radiation-induced Esophagitis w/Glutamine
Retinoids & Lung Ca-Right Population Needed

JNCI, 7/02 Non-smokers may benefit from vitamin A

Breath Test & Post-Operative Health J Chest, 7/02

Concentrated Carcinogens in Lung

J Applied Physiology, 4/03

Antioxidants:Vit C/E & Female Smokers

AACR Abstract #R3893 Continued need for supplementation

NAC as Chemopreventive for Bca
Familial Risk Lung Ca Reduced w/Folate & Vit B6
Dietary Carotenoids & Lung Ca Risk:Former Smokers
Mesothelioma Issues

Lancet, 11/03 Articles, Studies, LINKS

Gene Test Distinguishes Lung Adenocarcinoma from Mesothelioma
Single-Dose RTx & Mesothelioma: Ineffective
Lung Ca & Mesothelioma Screening w/Low-dose Spiral CT
Clove Extract Neutralizes Asbestos Fiber
Primary Peritoneal Mesothelioma: Treatment Issues
Organizations for Mesothelioma
Apigenin, Apoptosis & Pleural Mesothelioma Cells
Cancer Mortality in a Cohort of Asbestos Textile Workers
Surviving Mesothelioma w/Alt Therapies
Book: Surviving Mesothelioma and Other Cancers
Chemotherapy Doesn't Help in Malignant Mesolthelioma
Chlamydia pneumoniae & Lung Cancer: Epidemi Evidence

Cancer Epidem Biomark & Prevention, April, 2005

Lung Cancer Abstracts

Frontiers in Cancer Prevention Research, 2003

Behavior & Staten Island Lung Ca Cluster
4 Month Tea Intervention in Heavy Smokers
alpha-Tocopherol & Ascorbic Acid /beta-carotene/reinoids
Apigenin, Apoptosis & Pleural Mesothelioma Cells
Aspirin Cuts:Bowel, Lung, Mouth,Throat, Esophagus Risk

Br J Cancer, 3/03

Acupuncture for Post-Thoracotomy PAIN

LINK to Trial Memorial Sloan Kettering, NYC 8/04

Lung Cancer Advocacy/Support Groups

Links to groups

Bonnie Jones's tale of Non-Small Cell Carcinoma
High Levels of Vitamin D Better Lung Ca Survival

Presented AACR, 2005

Nutritional status affects long term survival after lobectomy for lung ca

Lung Cancer. 2007 May 2007


Source: Havana Journal, June 08

Kanglaite USA

LINK to privately held biotechnology company. Kanglaite injection is a treatment for solid tumors, was approved by the Chinese Ministry of Health for people with advanced non small-cell lung cancer (NSCLC) and hepatocellular cancer in 1997, and in Russia for treatment of NSCLC in 2003.

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