Tumor Biology & Prognosis in Bk BCa Pts

A Review

ABSTRACT: American black women have a risk of developing breast cancer lower than that of American white women, but they have a worse prognosis when they do develop the disease. A major factor responsible for this discrepancy is a relatively high poverty level in the black population, with the consequent likelihood of delayed diagnosis and presentation with more advanced disease.

However, breast cancer in black women also occurs at a younger age, more often is estrogen receptor-negative, and more frequently exhibits aggressive biological behavior as judged by histopathologic grade, high tumor cell proliferation rate, and altered p53 expression. Obesity, known to be associated with a poor prognosis primarily as a consequence of increased estrogen production and bioavailability, is more common in black than in white breast cancer patients.

An additional factor may be an earlier age at first completed pregnancy for black women, which is associated with a reduced breast cancer risk but also a poorer prognosis. Both the epidemiologic features and the tumor biology of breast cancer in black women serve to stress the particular importance of developing effective, specifically tailored strategies for early diagnosis in this ethnic group.

[02/06/2001; Cancer Detection & Prevention]

Functionally Active Estrogen Receptor Isoform Different in Bk/Wh

Cancer Online, 2/02

ER+ Bca in African-Am Women Identified via PCA
Phenotype Postmeno Afr-Am Women Assoc w/ Increased Risk
Hormone Receptors: Racial Differences

Breast Cancer Research & Treatment, 5/02

Genetic/Repro Factors & Bca Risk

Genetic Epidemiology, 5/02

Retrospective Analysis:Young AA Females

Breast Cancer Res Treat, 3/03

Gene BP1 More Often Active in Black Women

J Breast Ca Res, 4/03

White Blood Cell Counts & Treatment Delay

JNCI, 10/03

Racial Differences in Expression of Cell Cycle Reg Proteins

Cancer, 4/04

Ethnicity & Breast Ca: Women's Health Init

ASCO, 2004

Impact of Pt Factors & RT-assoc Cardiac Perfusion Problms

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