ABSTRACT: Effects of Estrogen plus Progestin on Health-Related
Quality of Life
Background: The Women's Health Initiative (WHI) and other clinical
trials indicate that significant health risks are associated
with combination hormone use. Less is known about the effect
of hormone therapy on health-related quality of life.
Results: Randomization to estrogen plus progestin resulted in no
significant effects on general health, vitality, mental health,
depressive symptoms, or sexual satisfaction. The use of estrogen
plus progestin was associated with a statistically significant
but small and not clinically meaningful benefit in terms of sleep
disturbance, physical functioning, and bodily pain after one
year (the mean benefit in terms of sleep disturbance was 0.4
point on a 20-point scale, in terms of physical functioning 0.8
point on a 100-point scale, and in terms of pain 1.9 points on
a 100-point scale). At three years, there were no significant
benefits in terms of any quality-of-life outcomes. Among women
50 to 54 years of age with moderate-to-severe vasomotor symptoms
at base line, estrogen and progestin improved vasomotor symptoms
and resulted in a small benefit in terms of sleep disturbance
but no benefit in terms of the other quality-of-life outcomes.
Conclusions: In this trial in postmenopausal women, estrogen plus
progestin did not have a clinically meaningful effect on health-related
quality of life.
[05/08/2003; New England Journal of Medicine]
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