ABSTRACT: Neoadjuvant chemotherapy and hyperthermia improve tumor
reoxygenation in patients with locally advanced breast carcinoma
Purpose/Objective: Tumor hypoxia has long been associated with
Drug resistance, angiogenesis, cytokine
production, cell cycle control, apoptosis and development of
distant metastases are also influenced by hypoxia.
tumor hypoxia could significantly influence tumor treatment
response. The objective of this study was to determine whether
neoadjuvant chemotherapy in combination with hyperthermia (HT)
would improve oxygenation in locally advanced breast tumors.
Conclusions: These preliminary results suggest that
oxygenation of locally advanced breast carcinoma correlates with
response to treatment,
2) the combination of neoadjuvant
chemotherapy and hyperthermia improves oxygenation in locally
advanced breast tumors that are initially hypoxic.
patients and longer followup are necessary for confirmation.
11/14/2002; International Journal of Radiation Oncology, Biology, Physics
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