Neoadjuvant Chemo/Hyperthermia

ABSTRACT: Neoadjuvant chemotherapy and hyperthermia improve tumor reoxygenation in patients with locally advanced breast carcinoma

Purpose/Objective: Tumor hypoxia has long been associated with radiation resistance.

Drug resistance, angiogenesis, cytokine production, cell cycle control, apoptosis and development of distant metastases are also influenced by hypoxia.

Decreasing tumor hypoxia could significantly influence tumor treatment response. The objective of this study was to determine whether neoadjuvant chemotherapy in combination with hyperthermia (HT) would improve oxygenation in locally advanced breast tumors.

Conclusions: These preliminary results suggest that

1) tumor oxygenation of locally advanced breast carcinoma correlates with response to treatment,

2) the combination of neoadjuvant chemotherapy and hyperthermia improves oxygenation in locally advanced breast tumors that are initially hypoxic.

Additional patients and longer followup are necessary for confirmation.

11/14/2002; International Journal of Radiation Oncology, Biology, Physics

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