ABSTRACT: Molecular markers in Paget disease of the breast
[07/11/2001; Journal of Surgical Oncology]
Background and Objectives: Molecular markers are increasingly being
analyzed in tumor specimens because of their relevance to both prognosis
and choice of therapy.
Paget disease of the breast is an uncommon
form of breast cancer, in which molecular markers have not been
well characterized. The objective of this study was to investigate
the expression of c-erbB-2, p53, Ki-67, Cyclin D1, Bcl-2, estrogen
receptors (ER), and progesterone receptors (PR) in mammary Paget
Conclusions: Tumors from patients with Paget disease of the
breast were positive for c-erbB-2, Cyclin D1, and Ki-67,
molecular markers commonly associated with more aggressive
tumor behavior and poorer survival in breast cancer patients.
Few of these tumors expressed Bcl-2 or ER and PR, which are
generally associated with a better prognosis. Similar expression
of these markers in both Paget cells and the underlying
carcinoma supports the theory that these cells are
the result of an intraepidermal spread of ductal carcinoma.
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