ABSTRACT: Mitoxantrone and methotrexate chemotherapy with and
without mitomycin C in the regional treatment of locally advanced
Fifty patients with locally advanced breast cancer received regional
chemotherapy delivered angiographically via the internal mammary
artery and varying vessels supplying the lateral aspect of the
breast. Thirty three patients received mitomycin C, methotrexate
and mitoxantrone, and 17 patients received methotrexate and mitoxantrone
only. There was no significant difference in clinical response
between the two groups. However, in patients who received mitomycin
C, severe local skin toxicity occurred in nine patients resulting
in delay of further therapy and considerable morbidity.
C should not be administered regionally in patients with locally
advanced breast cancer.
[02/08/2002; The Breast]
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