Sentinel Lymph Node Vital In Determining Need For Complete Dissection
[06/18/2001; Doctor's Guide]
Characteristics of the sentinel lymph node can provide information
to help determine the need for complete axillary lymph node dissection
in invasive breast cancer.
"Complete lymph node dissection may not be necessary in patients
with micro-metastases detected initially by cytokeratin staining,"
say researchers from the University of South Florida at Tampa.
They report that in cases detected by cytokeratin staining, cancer
is confined to the sentinel lymph node 92.4 percent of the time.
"Variables such as the size of the primary tumor, the volume of
disease in the sentinel lymph node and the method of detection
of micro-metastases can predict further involvement of neighbouring
non-sentinel lymph nodes," investigators point out.
"Sentinel lymph node biopsy is an accurate method for nodal staging
in patients with breast cancer, and when combined with detailed
histologic examination of the sentinel lymph node, a sub-group
of patients who may not require complete lymph node dissection
can be identified."
Archives of Surgery, 6/01
Am Soc Breast Disease Annual Symp, 4/03
Am J Surgery, 10/03
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