Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumor growth.
Liu N, Lapcevich RK, Underhill CB, Han Z, Gao F, Swartz G, Plum SM, Zhang L, Gree SJ.
Abstract: In this study, a hyaluronan-binding complex, which we termed Metastatin, was
isolated from bovine cartilage by affinity chromatography and found to have both
antitumorigenic and antiangiogenic properties.
Metastatin was able to block the
formation of tumor nodules in the lungs of mice inoculated with B16BL6 melanoma
or Lewis lung carcinoma cells.
Single i.v. administration of Metastatin into
chicken embryos inhibited the growth of both B16BL6 mouse melanoma and TSU human
prostate cancer cells growing on the chorioallantoic membrane.
The in vivo
biological effect may be attributed to the antiangiogenic activity because
Metastatin is able to inhibit the migration and proliferation of cultured
endothelial cells as well as vascular endothelial growth factor-induced
angiogenesis on the chorioallantoic membrane.
In each case, the effect could be
blocked by either heat denaturing the Metastatin or premixing it with
hyaluronan, suggesting that its activity critically depends on its ability to
bind hyaluronan on the target cells.
Collectively, these results suggest that
Metastatin is an effective antitumor agent that exhibits antiangiogenic
Cancer Res 2001 Feb 1;61(3):1022-8
|Remember we are NOT Doctors and have NO medical training.|
This site is like an Encyclopedia - there are many pages, many links on many topics.
Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.