ABSTRACT: Male Breast Cancer: A Reappraisal of Clinical and Biologic
Indicators of Prognosis
[08/13/2001; Acta Oncologica]
Between 1970 and 1998, 90 cases of male breast cancer
with available pathological material were retrieved. The disease
often presented in aged patients (median - 66 years) and as advanced
stage (stage III/IV - 51%).
Excluding stage IV disease, the neoplasia
were predominantly ductal invasive carcinomas, NOS (not otherwise
specified) (92%), grade 1 and grade 2 (94%), positive for estrogen
and progesterone receptors (72% and 74%), negative for androgen
receptors (100%), p53 negative (95%), c-erbB-2 negative (88%)
and DNA aneuploid (73%).
Assessment of disease outcome is determined
by stage at time of diagnosis, and axillary lymph node status
was the only parameter found to have a statistically significant
correlation with either disease-free interval or overall survival
(p < 0.001) by multivariate analysis.
Clinically useful information
on the probability of relapse can be added by determining c-erbB-2
(p = 0.02) and progesterone receptors (p = 0.04) in stage III
and tumor ploidy (p = 0.04) in pN1 subgroups of patients.
|Remember we are NOT Doctors and have NO medical training.|
This site is like an Encyclopedia - there are many pages, many links on many topics.
Support our work with any size DONATION - see left side of any page - for how to donate. You can help raise awareness of CAM.