Invasive carcinomas of the male breast: a morphologic study of the distribution of histologic subtypes and metastatic patterns in 778 cases
Ana M. Burga1, 3, Oluwole Fadare2, 4, 5, 7 , Ruth A. Lininger1, 6 and Fattaneh A. Tavassoli1, 2
(1) Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
(2) Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
(3) Department of Pathology, Englewood Hospital, Englewood, NJ, USA
(4) Department of Pathology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, TX, USA
(5) Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
(6) Department of Pathology, University of North Carolina, Chapel Hill, NC, USA
(7) Department of Pathology, Wilford Hall Medical Center, 2200 Bergquist Dr., Ste 1, Lackland AFB, TX 78236, USA
Abstract The current investigation was conducted to evaluate the proportional distribution of the various histologic subtypes (including newly recognized variants) of male breast carcinomas, to determine whether any histologic subtypes occur with a frequency that is markedly discordant with the expected frequencies from published data on parallel female breast tumors.
We also aimed to document the distribution of malignancies metastatic to the breast. Seven hundred fifty-nine archived cases of primary invasive carcinoma involving the male breast were retrieved and subcategorized into histologic subtypes according to contemporary criteria.
Six hundred forty-three (84.7%) tumors were pure infiltrating ductal carcinoma (IDC) not otherwise specified.
The most common of the remainder included papillary carcinoma with invasion in the form of IDC (n=34), mixed IDC and mucinous carcinoma (n=26), and pure mucinous carcinoma (n=21).
In 19 cases, metastases from other sites involved the breast, most commonly (58%) cutaneous melanoma. Invasive carcinoma of the male breast appears to display a morphologic spectrum and distribution of histologic subtypes that is comparable to those of the female breast, with some expected variation.
Compared with published experience on their female counterparts, there is a two-fold increase in the frequency of invasive papillary carcinoma in the male breast.
Finally, the most common tumor metastatic to the male breast in this series was cutaneous melanoma.
ISSN 0945-6317 (Print) 1432-2307 (Online)
Issue Volume 449, Number 5 / November, 2006
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