ABSTRACT: Effect of Lower Doses of Conjugated Equine Estrogens
With and Without Medroxyprogesterone Acetate on Bone in Early
Context: Lower-than-commonly-prescribed doses of conjugated equine
estrogens (CEEs) with medroxyprogesterone acetate (MPA) improve
vasomotor symptoms and vaginal atrophy, provide acceptable bleeding
and lipid profiles, and afford endometrial protection. This lower-dose
therapy's protection against loss of bone mineral density (BMD)
associated with menopause has not been thoroughly investigated.
Objective: To determine the effects of lower doses of CEEs only or CEEs-MPA
on spine and hip BMD, total body bone mineral content (BMC),
and biochemical markers of bone turnover in postmenopausal women.
Conclusions: Doses of CEEs or CEEs-MPA lower than 0.625 mg/d effectively
increase BMD and BMC in early postmenopausal women.
[05/22/2002; Journal of the AMA (Free Registration Required)]
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