Local Hyperthermia & External RTx: Locoregional BCa

Local hyperthermia combined with external irradiation for regional recurrent breast carcinoma

ORIGINAL ARTICLE

Gong Li1, Michihide Mitsumor, Masakazu Ogura1, Naotoshi Horii2, Sachiko Kawamura1, Shin-ichiro Masunaga3, Yasushi Nagata1 and Masahiro Hiraoka1

(1) Department of Therapeutic Radiology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan (2) Department of Radiology, Kishiwada City Hospital, Kishiwada, Japan (3) Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Kyoto, Japan

Backgrounds The purpose of this study was to evaluate the therapeutic effects of hyperthermia in combination with radiotherapy for locoregional recurrence of breast cancer, and to assess the factors related to subsequent local tumor control.

Methods Between March 1981 and February 2001, 85 lesions in 73 patients were treated with local hyperthermia combined with external irradiation. Of 75 evaluable lesions, 41 were previously irradiated.

Mean radiation dose to the previously unirradiated area was 59.5 6.8Gy (range, 4070Gy), while a total dose of 43.0 12.4Gy (range, 1274.4Gy) was administered to previously irradiated tumors.

Hyperthermia was administered once or twice per week. The average number of hyperthermia sessions was 4.5 (29). Results Complete responses (CRs) were achieved in 56% (23/41) of previously irradiated and 47% (16/34) of unirradiated tumors.

There was no significant difference in the CR rate between the two groups. Compared with the response of bulky/nodular tumors, diffuse/multiple small nodular tumors showed a higher CR rate at 4 weeks after treatment.

However, at 6 months after treatment, they showed a significantly lower local control rate.

Conclusions The present findings suggested a significant benefit of local hyperthermia combined with radiotherapy in the treatment of locally recurrent breast cancer, especially for previously irradiated recurrence, by reducing the total irradiation dose.

Diffuse/multiple small nodular tumors respond earlier than bulky/large nodular tumors; however, they tend to recur within the treatment field.

International Journal of Clinical Oncology ISSN: 1341-9625 (Paper) 1437-7772 (Online) DOI: 10.1007/s10147-004-0395-3

Volume 9, Number 3Date: June 2004 Pages: 179 - 183


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Thanks to Science Daily, Jan 2010 Annals of Surgical Oncology


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