Leukemia  & Lymphoma Issues

October 2010: Less Intensive Treatment OK for early stage Hodgkin's Lymphoma (see story item below in Lymphoma section)

May 2009 reported at the American Academy of Neurology meeting

Higher-Than-Expected Leukemia Rates Seen with Mitoxantrone in MS patients

Italian multiple sclerosis patients treated with mitoxantrone (Novantrone) developed leukemia at up to 10 times the rate seen in previous studies, researchers reported here.

In 2000, it was approved by the FDA for treating multiple sclerosis, including the relapsing-remitting and primary and secondary progressive forms. However, the drug is less popular for these conditions in the U.S. than in Europe, said Dr. Martinelli.

In addition to the previously known risk for acute leukemia, the drug is also cardiotoxic and causes neutropenia with an associated risk of infection. It carries a boxed warning about these effects.

The study examined records of all patients with multiple sclerosis treated with mitoxantrone since 1999 at the participating hospitals. Inclusion criteria included a minimum of one treatment cycle and one year of follow-up.

A total of 2,854 patients were identified, of whom 21 developed acute leukemia, with eight deaths.

Martinelli V, et al "Incidence of acute leukemia in multiple sclerosis patients treated with mitoxantrone: a multicenter retrospective study" AAN Abstract LB3.001

Our source: www.medpagetoday.com

Bone Mass & Vit D Deficiency

Leukemia, 12/01

BMD, then Vit D Therapy
Stop High-Caffeine Foods, Add Exercise
Fruit /Veg intake is Assoc w/Increased Bone Mass
Pamidronate & 1,24(S)-dihydroxyvitamin D-2 inhibited growth of cancer cells
Walking Intervention: Fatigue Experiences of Hospitalized AM L Pts Undergoing Chemo

Journal of Pain and Symptom Management, March 2008 Article in Press, Corrected Proof

Walking May Relieve Fatigue in Leukemia Patients
Clinical trial: vit C against non-Hodgkin lymphoma

www.lef.org January 2008

White Bld/Neutrophils Rise w/Massage

J Bodywork & Movement Therapies, October, 2001

Nitric Oxide Against Leukemia

J Molecular Cancer Thera, 4/03

Future Cancer Risk for Stem Cell Transplant Patients

Cancer (online), 11/06

Aspirin & Reduced Leukemia Risk

Cancer Epidem, 6/03

Link Between Maternal Diet and Childhood Leukemia Risk

Source: National Institutes of Health (NIH) September, 2004

Childhood Leukemia - Meta-analysis of Proximity Nuclear Facilities
Body RTx / Hyprthrmia:Dendritic Immnthpy

AACR Abstract #LB-108, 2003

Leukemia/Lymphoma Abstracts

Various Abstracts from 2003 Frontiers in Cancer Prevention Research AACR

Dietary B Vitamins & Lymphoid Cancer Risk:Male Smokers
Lymphoma Issues

Articles, LINKS

Ridiculous article on Diffuse large-B-cell
Chinese Medicine & Malignant Lymphoma
Increased Morbidity/Mortality & Involved Field RTx
Fatigue in Long-term Survivors of Hodgkin's Lymphoma
Lymphoma & Psoriasis
Hepatitis C Virus & Risk of Non-Hodgkin's Lymphoma
Non-Hodgkin's L & Type of Tobacco Smoke
Chlamadyiae & Ocular Lymphoma Related
Hodgkin Lymphoma & Multiple Sclerosis
Subclinical Late Cardio Problems w/Doxorubicin: Lymphoma
Excess Risk of Ovarian Ca & Lymphoma
Non-Hodgkin's Lymphoma in Asthmatics Exposed to Pesticides
NCI Creates Model to Predict Follicular Lymphoma Survival
Methotrxate Linked to Lymphomas
Vegetable Nutrients Lower Risk: Non-Hodgkin Lymphoma
Complete Remission in Relapsed Follicular Lymphoma Pts
Less Intensive OK for Early Stage Hodgkin's Lymphoma
Info Natural Therapy Leukemia/Lymphoma

Various studies, articles links, etc.

Boswellic Acid Acetate Kills Ca Cells (in vitro)
Chinese Herb contains Flavinoid -Cancer Fighter
Effect of Aplidin (Marine substance) in ALL cells
Resveratrol as Inducer of Apoptosis(Cell Death)
Bovine Lactoferricin Kills Cancer Cells (in vitro)
VEGF Receptor & Green Tea: CLL
Coriolus versicolor extract & human leukemia xenografts
Oridonin Inhibits Lymphoid Ca Cells(Rabdosia rubescens)
Piplartine induces inhibition of leukemia cell
Cannabidiol-induced apoptosis in human leukemia cells
Flavonoid compound kills leukemia cells
Pot Compound Enhances Efficacy Of Anti-Cancer Agents
Dandelion Leaves Fight Cancer
Carrot Juice and Leukemia Cells
Yeast Infections & Leukemia

Clin Infect Diseases, 2/04

Recovery/Long-term Function AFTER Transplant

JAMA, 5/04

Be ADVISED: AML  Unanswered Questions

Lancet Oncol, 7/04

Ecstasy & Antidepressants Block Cancer Growth: Leukemia

University of Alabama, Birmingham, 5/05

Leukemia and Lymphoma Groups

LINKS to various organizations

Protective effect of hawthorn extract:cyclophosphamide (Mice)

Environmental Toxicology and Pharmacology January 2008

Forskolin Suppressive of Leukemia Progression

Cancer Cell, 11/05

Trisenox & Vit A Analog for APL

Am Soc of Hematology, 12/03

Combined Chemo Improves CLL Outcomes but Not Survival

Lancet, July 2007

imatinib (Gleevec)

ASCO 2006

Dasatinib Therapy for Leukemia May Lead to Lung Problems

Am J Respir Crit Care Med, 11/07

Synergistic Reversal effect quercetin & hyperthermia: doxorubicin

International Journal of Hyperthermia, January 2008

Fatty Acid to Enhance Anticancer Drug Azacytidine

Molecular Cancer Therapeutics, 2010

Drug Interactions with Tyrosine Kinase Inhibitors (CML)

J Blood, September 2010

Doctor Writes About 2 Weeks in the Transplant Unit

December 2010 HemOncToday.com

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