ABSTRACT: Lacrimal Duct Stenosis and Other Ocular Toxicity Associated
with Adjuvant Cyclophosphamide, Methotrexate and 5-Fluorouracil
Combination Chemotherapy for Early Stage Breast Cancer
Certain side-effects of chemotherapy are well recognized
but ocular toxicity is often underestimated. This retrospective
study was undertaken after we became aware of a case of irreversible
lacrimal duct stenosis in a woman receiving adjuvant chemotherapy
for early stage breast cancer.
Using the chemotherapy records,
128 patients who received adjuvant cyclophosphamide, methotrexate
and 5-fluorouracil combination chemotherapy for early stage breast
cancer over a 2 1/2-year period were identified.
The case notes
of these patients were reviewed and an 18% incidence of ocular
side-effects, including four other cases of epiphora, was identified.
The epiphora resolved fully on completion of chemotherapy in
these four patients but not in the index patient.
management of these side-effects is unclear but it needs to be
tailored to the particular toxicity experienced by the patient.
[12/24/2001; Clinical Oncology]
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