ABSTRACT: A double-blind randomized controlled trial of isoflavones
in the treatment of cyclical mastalgia
Cyclical mastalgia is very common in Western populations and is
believed to have an hormonal basis. Simple measures such as vitamins
or evening primrose oil are not very effective, yet the disease
rarely warrants anti-oestrogen therapies.
Isoflavones are a subgroup
of phytoestrogens which we hypothesized might be a simple and
effective means of therapy as they act as a weak anti-oestrogen
in pre-menopausal women and have no side-effects.
randomized control trial of either placebo, 40 mg or 80 mg of
isoflavones was undertaken after an initial 2 month single-blind
'Placebo Lead-in' to exclude women with a significant placebo
Eighteen women were randomized to the treatment phase
of the trial. Nine of the 12 women on treatment had a worthwhile
improvement in their pain compared to only two of six on placebo.
The reduction in pain was 13% for placebo, 44% for 40 mg of isoflavone
per day and 31% for 80 mg per day.
There have been no previous
clinical studies of isoflavones for the treatment of mastalgia
and the benefit demonstrated in this study adds another valuable
arm to therapy.
[06/03/2002; The Breast]
Cancer Detection & Prevention, 10/02
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