Induction of AP-1 Activity by Perillyl Alcohol in Bca Cells

Induction of AP-1 activity by perillyl alcohol in breast cancer cells.

Satomi Y, Miyamoto S, Gould MN.

McArdle Laboratory for Cancer Research, Department of Pharmacology, University of Wisconsin-Madison, Madison, WI 53792, USA.

Monoterpenes display chemopreventive and therapeutic activity in rat mammary tumor models. Monoterpenes can also inhibit cell growth and induce apoptosis of cultured cells.

In this study, the monoterpene perillyl alcohol (POH) was found to induce transient expression of the c-jun and c-fos genes transcriptionally. POH also transiently induced phosphorylation of c-Jun protein. These events were associated with transcriptional activation of an AP-1-dependent reporter gene.

These results suggest that POH might affect c-Jun activity via the Jun N-terminal kinase/stress-activated protein kinase pathway and modulate expression of AP-1 target genes.

Carcinogenesis 1999 Oct;20(10):1957-61

Ann's NOTE: Perillyl Alcohol is from Lavender and has been shown to be of benefit in what is called 'chemoprevention' but refers to prevention of cancer through 'natural' substances.

Phase I Trial Perillyl Alcohol in Human Subjects

Cancer Chemo & Pharma, 6/03

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