Indole-3-carbinol

What We Know Now

Summary of recent studies (2002) shows that this vegetable extract:

Increased the conversion of estradiol to the safer estriol by 50% in twelve healthy people in just one week.

Prevented the formation of the carcinogenic estrogen metabolite 16-alpha-hydroxy estrone in two months in 17 men and women.

Stops human cancer cells from growing (54-61%) and provokes the cells to self-destruct (apoptosis).

Inhibits MCF7 human breast cancer cells from growing by as much as 90% in culture.

Inhibits an estrogen metabolite (16-alpha-hydroxyestrone) that prompts breast cancer cells to grow.

Competes with dioxin for the Ah receptor to help keep dioxin out of cells.

Prevented chemically-induced breast cancer in rodents by 70-96%.

Prevented other types of cancer, including aflatoxin-induced liver cancer,leukemia and colon cancer.

Thanks to the Life Extension Foundation for this summary. See their website below for more on this or go to the "ABOUT THE LINKS" section for a direct link.

http://www.lef.org/cgi-local/welcome.cgi/id=2659/sgroup_id=699/welcome.html


Inhibitory: Indole 3-carbinol & Human Bca cells

Breast Ca Res Treat, 9/02

Indole-3-Carbinol Potent Oral Anticancer Activity
High Dose I3C and Crambene Protective
BRCA1/2 Molecular Targets for Indole-3-carbinol/Genistein
Diindoylmethane: For Estrogen Metabolism

"Safer Estrogen w/Phytonutrition" Michael A. Zeligs, MD Thanks to Mid-Hudson Options Project

Indole-3-carbinol:Neg Regulator Estrogen
DIM/I3C Safety Information

Source: http://www.dimfaq.com/site/I3C-safety.htm Michael A. Zeligs, MD

References
DIM may Treat & Prevent Cancer
Two Talks Excerpted  9/02: I-3C

Nutritional Genomics & Proteomics in Cancer Prevention, 9/02

Indole-3-carbinol/Hepatoxicity ET-743 Protects Female Rats

Intl J Cancer, 10/04

I-3C Blocks Cancer Cells via molecule called Cdc25A

J Cancer Prevention Research, June 2010


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