I-3-c, DIIM Induce Apoptosis:Prostate Ca Cells

Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells.

Nachshon-Kedmi M, Yannai S, Haj A, Fares FA.

Abstract: Faculty of Food Engineering and Biotechnology, Technion- Israel Institute of Technology, 32000, Haifa, Israel.

Cruciferous vegetables contain glucobrassicin which, during metabolism, yields indole-3-carbinol (I3C). In a low pH environment I3C is converted into polymeric products, among which 3,3'-diindolylmethane (DIM) is the main one.

The apoptotic effects of I3C and DIM were exhibited in human breast cancer cells. The objectives of this study were: (a) examination of the potential effects of I3C and DIM on the proliferation and induction of apoptosis in human prostate cancer cell lines with different p53 status; (b) to try to characterise the mechanism(s) involved in these effects.

Our results indicate that both indole derivatives suppress the growth of these cells in a dose- and time-dependent manner, by inducing apoptosis. It appears that these indolic compounds may offer effective means against prostate cancer.

Induction of apoptosis was p53-independent. Moreover, the indole derivatives employed did not affect the levels of bcl-2, bax and fasL.

Food Chem Toxicol. 2003 Jun;41(6):745-52.

Inositol hexaphosphate (IP6)& Mouse Prostate Cells

Int J Oncol, 11/03

Diindolymethane:Anti-Metastatic Prostate CA

Abstract #C171 Frontiers in Cancer Prevention Res, 2003

Induction of Apoptosis (Cell death) in Human Prostate Ca  Lines

British J Cancer, 8/04

Indole-3-carbinol & Prostate Cancer

J Nutr, 12/04

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