ABSTRACT: Menopausal Hormone Replacement Therapy and Risk of Ovarian
Context: The association between menopausal hormone replacement
therapy and ovarian cancer is unclear.
Objective: To determine whether hormone replacement therapy
using estrogen only, estrogen-progestin only, or both estrogen
only and estrogen-progestin increases ovarian cancer risk.
Conclusion: Women who used estrogen-only replacement therapy,
particularly for 10 or more years, were at significantly
increased risk of ovarian cancer in this study.
Women who used
short-term estrogen-progestin-only replacement therapy were
not at increased risk, but risk associated with short-term and
longer-term estrogen-progestin replacement therapy warrants further
07/17/2002; Journal of the AMA
Cancer Detection & Prevention, 4/05
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