HRT Does NOT Reduce CHD Events

Cardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy: Heart and Estrogen/Progestin Replacement Study Follow-up (HERS II)

Context: The Heart and Estrogen/progestin Replacement Study (HERS) found no overall reduction in risk of coronary heart disease (CHD) events among postmenopausal women with CHD.

However, in the hormone group, findings did suggest a higher risk of CHD events during the first year, and a decreased risk during years 3 to 5.

Objective: To determine if the risk reduction observed in the later years of HERS persisted and resulted in an overall reduced risk of CHD events with additional years of follow-up.

Conclusions: Lower rates of CHD events among women in the hormone group in the final years of HERS did not persist during additional years of follow-up.

After 6.8 years, hormone therapy did not reduce risk of cardiovascular events in women with CHD.

Postmenopausal hormone therapy should not be used to reduce risk for CHD events in women with CHD.

[07/03/2002; Journal of the AMA (Free Registration Required)]

HRT Study from the Lay Perspective

New York Times, 7/10/02

ERT/PRT Gives Increased Risk Too

Cancer Causes & Control, 10/02

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