HORMONAL BLOCKADE THERAPY
DR. ISRAEL BARKEN
PROSTATE CANCER RESEARCH AND EDUCATION FOUNDATION,
LOS ANGELES, CA.
Dr. Barken used the first portion of his allotted time to make a plea for contributions to his PCRE Foundation. Dr. Myers, who was moderating the session, had to pound his gavel to get Dr. Barken to focus on the topic of his paper.
Since Dr. Myers Foundation was a principal sponsor of the event, he objected to another smaller foundation soliciting support from the podium. Dr. Barken uses funds from his Foundation to support early initial ideas and hypotheses that might offer advances in our knowledge of prostate diseases.
He did deliver a lecture on the overall topic of hormonal blockade included the sub-categories of androgen blockade and blockade of testosterone production by the testes. He reviewed the traditional usage of LHRH agonists and the standard Casodex/Flutamide therapies.
Dr. Barken also commented on the need to separate treatments according to whether they are for local disease, locally advanced disease, or pelvic node disease. Essentially, he made the argument that HB and/or IHB are empirical approaches to dealing with hormonal refractory conditions.
Time to reach PSA nadir, time off hormone blockade treatments, time to rise of PSA are all parameters that are highly dependent on the specific nature of a given case of PCa.
[Ed Note: the common thread that ran through the several presentations on hormonal blockade therapy was the need to know as much about the PCa characteristics as was possible. Important parameters for predicting likelihood of success with HB and/or IHB include original Gleason Score, PSA at time of DX, time to PSA Nadir, etc.
For men who experience PSA relapse after primary therapy, all known parameters of their disease should be assembled so the treating oncologist can maximize his treatment plan].
MORE TO COME
International Prostate Cancer Conference, October 2006
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