Gonzalez Method-Metabolic Enzymes

Excerpt from the Moss Reports, June 22, 2008

Many readers have asked what happened to the National Institutes of Health-sponsored clinical trial of the Gonzalez regimen, the one that used orally administered enzymes for the treatment of pancreatic cancer?

In the 1980s, Nicholas Gonzalez, MD, was a disciple of Robert A. Good, MD, PhD, director of Sloan-Kettering Institute, New York. With Good's encouragement, he began a project (while still a Cornell medical student) to evaluate the enzyme treatment of cancer promoted by William Donald Kelley, DDS, of Grapevine, Texas.

Gonzalez felt this treatment was beneficial and eventually opened an office in Manhattan to treat patients using this protocol. He presented 25 of his best cases to the NCI's Division of Cancer Treatment (DCT) in July 1993. The pilot study was published in 1999 in the journal Nutrition and Cancer (Gonzalez 1999). Because of the positive findings of this pilot study, first the National Cancer Institute and then the National Center for Complementary and Alternative Medicine (NCCAM) proposed a formal clinical trial of the method.

A decade ago, hopes were high and this trial was promoted as a sterling example of how conventional and alternative medicine could work together for the good of patients, by seeking the truth about the relative merits of various contesting treatments. For example, John Chabot, MD, of the Herbert Irving Comprehensive Cancer Center of Columbia University, and Dr. Gonzalez spoke from the same podium at the 1999 Center for Mind-Body Medicine conference. It seemed like a transcendent moment.

For the full report:


Nicholas Gonzalez, MD

LINK to Nick Gonzalez, MD- works with supplements, diet detoxification. Announced 6/99 he has approved CLINICAL TRIAL for pancreatic cancer patients.

GONZALEZ: Meeting Report by Marilyn Holasek Lloyd

Comprehensive Cancer Care meeting, June 2000

Part II-Gonzalez Method
Audience reactions per Marilyn
Information on Dr. William D. Kelley

Originator of the Kelley Method

Dr. Jack Taylor Uses Metabolic Program

Includes Ann's personal experiences

Discussion of Trial and Barriers to Recruitment

10/02 Wired News

ALERT for Alternative Community
Pancreatic Enzyme Extract Improves Survival: Pancreatic

J Pancreas, 5/04

Pilot Study Report: Eval of Pancreatic Proteolytic Enzymes
National Cancer Institute - ABOUT Gonzalez Regimen

LINK to discussion of Nicholas Gonzalez, MD studies, program

Dr.Gonzalez at 2008 BoulderFest

tape of his talk available

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