Glycemic Index & BCA Risk

Annals of Oncology 12 (11): 1533-1538, November 2001

Dietary glycemic index and glycemic load, and breast cancer risk: A case-control study

L. S. A. Augustin Servizio di Epidemiologia, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and the Clinical Nutrition and Risk Factor Modification Centre, St. Michaelís Hospital, Toronto, Ontario, Canada

L. Dal Maso Servizio di Epidemiologia, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy

C. La Vecchia Istituto di Ricerche Farmacologiche ĎMario Negrií, Milan, Italy; Istituto di Statistica Medica e Biometria, Universitŗ degli Studi di Milano, Milan, Italy

M. Parpinel Servizio di Epidemiologia, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy

E. Negri Istituto di Ricerche Farmacologiche ĎMario Negrií, Milan, Italy

S. Vaccarella Servizio di Epidemiologia, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy; Field and Intervention Studies Unit, International Agency for Research on Cancer, Lyon, France

C. W. C. Kendall Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and the Clinical Nutrition and Risk Factor Modification Centre, St. Michaelís Hospital, Toronto, Ontario, Canada

D. J. A. Jenkins Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and the Clinical Nutrition and Risk Factor Modification Centre, St. Michaelís Hospital, Toronto, Ontario, Canada

S. Franceschi Servizio di Epidemiologia, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy; Field and Intervention Studies Unit, International Agency for Research on Cancer, Lyon, France

Abstract

Background: Certain types of carbohydrates increase glucose and insulin levels to a greater extent than others. In turn, insulin may raise levels of insulin-like growth factors, which may influence breast cancer risk.

We analyzed the effect of type and amount of carbohydrates on breast cancer risk, using the glycemic index and the glycemic load measures in a large case-control study conducted in Italy.

Patients and methods: Cases were 2569 women with incident, histologically-confirmed breast cancer interviewed between 1991 and 1994. Controls were 2588 women admitted to the same hospital network for a variety of acute, non-neoplastic conditions. Average daily glycemic index and glycemic load were calculated from a validated 78-item food frequency questionnaire.

Results: Direct associations with breast cancer risk emerged for glycemic index (odds ratio, OR for highest vs. lowest quintile = 1.4; P for trend <0.01) and glycemic load (OR = 1.3; P < 0.01). High glycemic index foods, such as white bread, increased the risk of breast cancer (OR = 1.3) while the intake of pasta, a medium glycemic index food, seemed to have no influence (OR = 1.0).

Findings were consistent across different strata of menopausal status, alcohol intake, and physical activity level.

Conclusions: This study supports the hypothesis of moderate, direct associations between glycemic index or glycemic load and breast cancer risk and, consequently, a possible role of hyperinsulinemia/insulin resistance in breast cancer development.

Copyright © 2001 Kluwer Academic Publishers All rights reserved


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