May 2009

A phase II/III randomized controlled (masked) study has been done by Dr Julie Ryan, assistant professor of Dermatology and Radiation Oncology and associates in the James P Wilmot Cancer Center at Rochester. In fact, this is the largest randomized study to show the effectiveness of ginger and the first to focus on taking the supplement before the chemotherapy.

The 644 human research subjects aka people with cancer about to take at least 3 courses of chemotherapy were also taking various doses of ginger along with anti-nausea pharmaceutical drugs once a day for 6 days starting three days BEFORE chemotherapy treatments. Those who took 1/2 gram to 1 gram of ginger found they had 40% less nausea than the other groups (those who took none or those who took a higher dose of ginger).

This information was excerpted from a story written by Catharine Paddock, PhD for Medical News Today.

Ann's NOTE: This trial should be conclusive evidence that ginger is very effective against nausea.

Ginger compound prevents growth of colorectal cancer cells

Research results presented on October 28, 2003 at the American Association for Cancer Research's Second Annual International Conference on Frontiers in Cancer Prevention Research showed that gingerol, a compound found in ginger that gives the spice its flavor, slowed the growth of human colorectal cancer cells.

Ann Bode and Zigang Dong of the University of Minnesota's Hormel Institute in Austin, Minnesota fed 500 micrograms [6]-gingerol three times weekly to a group of twenty mice before and after injecting them with human colorectal tumor cells.

Control mice injected with the cancerous cells received no [6]-gingerol . Tumors began to appear fifteen days after the mice received the cancer cells, with 13 tumors appearing in the control mice compared to four in the group that received [6]-gingerol .

Twenty-eight days after receiving the injections, all the mice in the control group had measurable tumors, compared to thirty-eight days for the treatment group.

After forty-nine days, 12 of the 20 treated mice still did not have tumors that had reached the size of one cubic centimeter, with tumors averaging half this size, while all of the control mice had already reached this point.

Dr Bode summarized, “Plants of the ginger family have been credited with therapeutic and preventive powers and have been reported to have anticancer activity.

The substance called [6]-gingerol is the main active compound in ginger root and the one that gives ginger its distinctive flavor . . .

These results strongly suggest that ginger compounds may be effective chemopreventive and/or chemotherapeutic agents for colorectal carcinomas. It's difficult to know if the ginger-treated mice would have lived longer if left to die of their tumors, but it looks that way.”

A new study is being planned that will administer ginger to mice after their tumors have progressed to a certain size.

-D Dye

Life Extension Foundation

Zingiber officinale (GINGER) as Antiemetic

Anaesthesia, 8/93

Ginger  for Nausea/Vomiting (Pregnancy)

Am J Ob & Gyn, 11/03

Element of Ginger Triggers Cell Death, Enhances Cisplatin

Abstract #2981 AACR, 3/04

Ginger  in prevention of nausea/vomiting after major GYN  surgery

J Med Assoc Thai, 2006; 89(4): 130-6.

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